In modern surgical dental practice, dentists often face the need to close soft tissue defects in the oral cavity. Recent research has been aimed at developing surgical methods that would ensure the sanitation of the inflammatory lesion, the revival of physiological processes at the site of the soft tissue defect, or create conditions for their recovery and ensure full function. The ease of access to the buccal fat pad arouses interest in its use for closing defects. The study aimed to analyze and study the literature data on various methods of using buccal fat pads for autotransplantation in the treatment of maxillofacial defects in comparison with the use of other grafts. Results: In recent years, methods of reconstructive plastic surgery using autografts have become widespread. There is evidence in the literature of positive results of surgical closure of tissue defects using autografting of adipose tissue and, in particular, the buccal fat pad. The buccal fat pad has its connective tissue capsule and a well-developed vascular network, which provides nutrition to the graft and rapid healing of the postoperative wound; it does not require preliminary preparation and adaptation to the recipient bed. This allows it to be used in maxillofacial surgery to close defects of the upper jaw, eliminate the oral-antral junction, reconstruction of intraoral defects, such as oroantral fistula, in the loss of mandibular bone mass in the areas of molars and premolars, to eliminate defects after treatment of oncological processes of the face. Conclusions: The favorable anatomical location, good blood supply, and almost complete absence of innervation of the buccal fat pad alleviate the surgeon's task and give better results of operations. The study proves the process of wound epithelialization one week after surgery and a stable clinical flow without complications in the long-term follow-up, which proves the relevance of the use of the buccal fat pad in modern maxillofacial surgery to improve existing and develop new methods of autotransplantation. Keywords: Buccal fat pad, maxillofacial defects, methods of reconstructive plastic surgery, osteoplastic materials, autografting, long-term follow-up