Taking into consideration the latest data on psoriasis problems, namely: a number of uncertain links of etiopathogenesis, possible consistency of disorders of immune system, thyroid and skin microbial landscape as well as failure to achieve long-term and controlled remission demonstrate the relevance and feasibility of further research of dermatosis, which will contribute to improving quality of life for patients by using appropriate methods of therapeutic correction. The aim of our research was to study of skin microbial landscape and immune-endocrine parameters as well as improvement of treatment efficiency in patients with different clinical course of psoriasis by using narrowband UVB phototherapy.