The aim: To establish the dynamics of reparation processes in periapical tissues in chronic granulomatous periodontitis under the influence of the developed composition based on calcium hydroxyapatite in comparison with the generally accepted drug MTA.
Materials and methods: The main group included 52 individuals, and the comparison group – 19 patients with chronic granulomatous periodontitis. In the first experimental subgroup, patients were obturated of the tooth root apical area with the proposed composition, and in the second experimental subgroup patients were performed obturation of the root canal apical area with additional transcanal withdrawal of the composition into the periapical area. In the comparison group, the tooth root apex was obturated with MTA material.
Results: Clinical studies have shown that the composition based on calcium hydroxyapatite, having osteoconductive, antioxidant and anti-inflammatory properties, activates the synthesis of organic and mineral components, that promotes the bioreparation and regeneration processes of periapical tissues in chronic granulomatous periodontitis, which occurred most intensively during the first 6 months after treatment. At the same time, with additional transcanal removal of the filling composition based on calcium hydroxyapatite into the periapical area in patients with chronic granulomatous periodontitis with acquired wide tooth root apex was observed in 1.6 time better results than the method of creating an apical root canal obturation (p <0,05), indicating a high therapeutic effect.
Conclusions: Composition based on calcium hydroxyapatite, having osteoconductive, antioxidant and anti-inflammatory properties, activates the synthesis of organic and mineral components, which promotes the processes of bioreparation and regeneration of periapical tissues, especially in the early stages. And additional transcanal removal of the filling composition into the periapical space causes the acceleration of the period of periodontal tissues revitalization, bioreparation and regeneration compared to the creation of the apical obturation within the physiological tooth root apex.
KEY WORDS: granulomatous periodontitis; composition based on calcium hydroxyapatite; regeneration; CDAP index