Research on the harmful effects of dental dust remains a relevant problem. The risk of bacterial and viral infections among dental personnel and patients has been a major research topic, especially during the coronavirus disease 2019 (COVID-19) outbreak. However, dental dust, as a common and potential health hazard, has not received sufficient attention.  For effective precipitation of dental dust particles, it is proposed to use aqueous solutions of
surfactants. The choice was made among 5 types of surfactants of natural origin: coco glucoside (CGl), decyl glucoside (DGl), Tween-80, cocamidopropyl betaine, rhamnolipid biocomplex (RBC).
The wetting properties of the solutions were characterized by surface tension and contact angle to the surface of the tooth and the filling composite material Latelux. A synergistic effect of nonionic surfactant compositions with RBC was established, which contributed to the acceleration of the sedimentation rate of model dental dust.
 Preparation of compositions based on physiological solution (0.9% NaCl) increased the effectiveness of the drug. According to the results of experiments, the formula of the preparation (g/l): CGl (0.25), DGl (0.25), RBC (0.2), NaCl (9.0) is optimal. The composition is characterized by efficiency and stability of action.