The results of the study show that with a two-week opioid exposure, the most prognostically favorable indicators were in the group where complete withdrawal was carried out with subsequent correction with the drug pentoxifylline. It can also be concluded that during the correction of opioid retinopathy, it cannot be carried out with drugs of the  antibradykinin group (pentoxifylline) without complete withdrawal of the opioid because  this contributes to a sharp increase in pathomorphological manifestations in the layers of the retina and is a prognostically unfavorable moment.