Increasing incidence of dermatosis at the background of reduced immunological response to the impact
of exo- and endogenous pathogenic agents dictate the necessity of a more profound research of the
problem. In addition, antibiotic and immunosuppressive therapy led to activation of saprobic and
conventionally pathogenic microflora which is believed to play a prevalent role in the development of
dermatosis and, in particular, psoriasis.
Purpose of the research was to study profile of epidermal microflora on the skin of psoriatic patients and
especially on the affected areas in order to determine its impact on the development and course of
psoriasis. 

Today, the use of platelet-rich plasma is increasing in clinical practice in various fields of medicine. The
plasma therapy is used by dermatologists, dentists, gynecologists, traumatologists and many other
specialists in daily practice.
Platelet-rich plasma is actively used in dermatology after its clinical effectiveness has been established.
The plasma therapy method alone, as well as in combination with other methods of treatment, has
shown advantages in certain skin diseases: androgenetic alopecia, alopecia areata, chronic vitiligo,
melasma, inflammatory nail disorders, psoriasis, acne, post-acne and seborrheic dermatitis.
Platelet-rich plasma can suppress cytokine release and limit inflammation by interacting with
macrophages, improving tissue healing and regeneration, promoting the formation of new capillaries
and accelerating epithelialization.
Plasma platelets also play an important role in the host's defense mechanism at the wound site by
producing signaling proteins that attract macrophages. Blood plasma also has antimicrobial activity
against Escherichia coli, Staphilococcus aureus, Candida albicans and Cryptococcus neoformans.
Currently, there is a large number of patients seeking medical help with seborrheic dermatitis.
However, the complexity of the pathogenesis of seborrheic dermatitis and its sensitivity to medications
require from the dermatologist a differential approach in choosing the local therapy.

The trace element imbalance is reflected in the condition and appearance of hair, which in its
composition have the following essential elements: nitrogen, sulfur, phosphorus, zinc, sodium, calcium,
magnesium and copper. The attention of many researchers is drawn to the hypothesis of the influence of
exogenous and endogenous factors on the functional state of the hair, especially essential and toxic
trace elements that cause dryness and thinning

The herpes simplex virus (HSV) may be not only a nosological disease but also a secondary infection
which may affect the severity of the course of other dermatoses.
On time diagnostic's and proper therapy of the psoriasis progression help related specialists prevent
occurrence of such diseases. Therefore, the goal of our research is to provide comprehensive
examination of the persons suffering from psoriasis, especially those with the severe or atypical course of
the disease, in order to detect herpetic infection and improve further treatment of these patients. 

Psoriasis is one of the most common chronic, non-communicable, immune-mediated skin diseases,
affecting over 125 million people worldwide. The means and dosage forms of topical therapy depend
usually on the clinical course pathological process. In recent years, both in the world and in Ukraine,
narrowband UVB phototherapy of psoriasis, because of its efficiency, safety and availability has become a
technique of choice in the treatment of psoriasis patients with different clinical course. NB UVB therapy
method is self-contained and can be used as monotherapy, but combination of emollient, in our view,
adds treat certain advantages. The aim of our study was to examine and evaluate the effectiveness of this
method phototherapy combination of emollient in the treatment of psoriasis.