Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide. The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization.
It has been established that patients with psoriasis, which were under observation, had the skin microbial landscape of the lesions formed mainly of S. aureus, S. epidermidis, S. saprophyticus, Bacillus and Micrococcus genera. The clearest microbial contamination of the lesions has been observed in psoriatic erythroderma, slightly less accentuated skin microbial contamination has been found in patients with the widespread form of dermatitis and the presence of arthropathy, and the least number of microorganisms have been found in patients with common psoriasis without complicated phenomena.
Squamous-hyperkeratotic mycosis of feet is the most prevalent dermatological condition in type 2 diabetes patients. The cutaneous symptoms develop slowly, starting with the formation of painless blistering and hyperkeratosis in areas exposed to pressure. The fungal infection adherence is promoted by poor circulation and traumatisation of the feet skin. The selection of a suitable product containing components with distinct keratolytic and hydrating effects is one part of the problem solution.
Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide.The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization. The results of conducted clinical, morphological and immunohistochemical investigations enable to consider importance of neoangiogenesis processes in pathogenesis of this dermatosis and need in elaboration of therapeutic measures with direct influence on this aspect of pathogenesis.
Characteristic сhanges in the macroorganism state are reflected in the disorders of microbial landscape of all topographical skin zones. It should be noted that the study of the skin microbial landscape in patients with psoriasis have episodic and unstructured nature. Thus, it is claimed that the findings of the skin microbiocoenosis disorder in patients with psoriasis are characterized by changes in the quantitative and qualitative spectrum of microorganisms, in particular, by the appearance of Staphylococcus haemolyticus in the foci, probable increase in the number of Corynebacterium spp., Micrococcus spp., Staphylococcus hominis, Staphylococcus capitis, Staphylococcus aureus on the background of an oppression or a significant increase in the colonization of Staphylococcus epidermidis. The purpose of our work was to investigate the quantitative composition of microscopic flora and the degree of skin induration of patients with psoriasis, depending on the clinical course (clinical form, stage) and duration of the disease.