The global spread of SARS-CoV-2 points to unrivaled mutational variation of the virus, contributing to a variety of post-COVID sequelae in immunocompromised subjects and high mortality. Numerous studies have reported the reactivation of "sluggish" herpes virus infections in COVID-19, which exaggerate the course of the disease and complicate with lasting post-COVID manifestations CMV, EBV, HHV6). This study aimed to describe clinical and laboratory features of post-COVID manifestations accompanied by the reactivation of herpes virus infections (CMV, EBV, HHV6). 88 patients were recruited for this study, including subjects with reactivation of herpes viruses, 68 (72.3%) (main group) and 20 (27.7%) subjects without detectable DNA of herpesviruses (control group): 46 (52.3%) female and 42 (47.7%) male; median age was 41.4 ± 6.7 years. Patients with post-COVID manifestations presented with reactivation of EBV in 42.6%, HHV6 in 25.0%, and EBV plus HHV6 in 32.4%. Compared with controls, patients with herpes virus infections presented with more frequent slight fever temperature, headache, psycho-neurological disorders, pulmonary abnormalities and myalgia (p < 0.01), activation of liver enzymes, elevated CRP and D-dimer, and suppressed cellular immune response (p ≤ 0.05). Preliminary results indicate a likely involvement of reactivated herpes virus infections, primarily EBV infections in severe COVID-19 and the formation of the post-COVID syndrome. Patients with the post-COVID syndrome and reactivation of EBV and HHV6 infections are at high risk of developing various pathologies, including rheumatologic diseases.

RATIONALE: Precision allergy molecular diagnostics allows assessment of cross-reactivity between pollen and food allergens using multiplex
measurement arrays.
METHODS: Data from 8016 ALEX tests performed in different regions of Ukraine in 2017-2019 were assessed in patients from 1 to 78 years old.Correlation analysis was performed by the Spearman method.
RESULTS: Cross-reactions were mostly seen with Betulaceae pollen groups. Sensitization to Alnus, Betula and Corylus pollen alone expressed cross-reactivity to other pollen types in 55-60 % of cases. 51 % of pateints sensitive to Bet v 2 profilin were sensitized to olive pollen profilin Ole e 2 and of date palm profilin Pho d 2. 51-53 % of patients were sensitized to PR-10 Bet v 1 of Betula pollen and Ara h 8 peanut allergen. 52 to 60 % of patients were sensitized to birch and alder pollen PR-10 allergens and to Mal d 1 of apple from the same group. Cross-reaction between alder and celery PR-10 allergens (Aln g 1 and Api g 1) was 50 %. 50 % of patients reacted to profilins of birch and latex (Bet v 2 and Hev b 8).
CONCLUSIONS: Pollen-targeted allergen-specific immunotherapy may possibly impact pollen-food oral allergy syndromes based upon allergen
cross-reactivit.