Psoriasis affects about2To of population In 30-40% of occurrences arthropathic
psoriasis (AP) is diagnosed and it leads to 11-19% of disability cases development. The article analyses features of
anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of
probable mechanisms of disease aggravation and progression with the definition of a treatment method
influencing the dynamics of a disease course.
The objective of our work was to improve the diagnostics of AP patients taking into account some indicators of
the inrmune-epdocrine system and features of the disease course to specify their role in AP pathogenests and to
develop the system of integrated therapy of patients whose locomotor system is affected due to psoriasis
The relevance of the problem of urticaria is generally recognized. The chronic infection foci, gastrointestinal diseases, diabetes mellitus, malignant neoplasms, etc. are among the factors that initiate the manifestation of the disease. However, the studies devoted to evaluation of the endocrine glands in such patients remain unaddressed. Although it is known that, in particular, the thyroid gland takes an active part in the development of allergic dermatoses. Objective: To study the thyroid hormone balance in patients with chronic idiopathic urticaria.
Toxic epidermal necrolysis (TEN) is one of the most severe reactions of the body to
the action of various xenobiotics with necrosis of the epidermis, mucous membranes and damage to internal
organs, which is accompanied by profound disorders of hemodynamics and homeostasis, often leading to death.
A wide range of bioregulatory effects of nitric oxide, in particular, participation in the development and course of
allergic inflammation (cytotoxic, immunocomplex reactions), suggest the participation of nitric oxide in the
pathogenesis of TEN
Останніми роками дерматологи все частіше звертають увагу на проблему взаємозв’язку захворювань шкіри із вживанням лікарських препаратів. Під нашим спостереженням перебували 64 хворих із ТАД, які проявлялися багатоформною ексудативною еритемою, синдромом Стівенса—Джонсона та токсичним епідермальним некролізом. Лікувальна тактика хворих на токсико-алергійні дерматози має ґрунтуватись на урахуванні чин- ників, що призводять до розвитку цих станів.
Stevens–Johnson syndrome (SJS), which is a drug-induced disease in 50% of cases, is increasingly common in everyday practice. A determining role in the pathogenesis of pathological conditions (inflammation, shocks of various genesis, etc.) plays a unique extra- and intracellular messenger, i. e., the nitrogen oxide (NO) system acts as an endogenous regulator in various dermatoses. In physiological concentrations, NO interacting with reactive oxygen species exhibits antioxidant properties, in case of metabolic disorders associated with the NO accumulation in tissues, and said reactions promote highly toxic substances adversely affecting the disease course. The NO biological action wide scope determines the interest in studying the NO-NOS system (nitrate ions (NO3-), nitrite ions (NO2-)) in patients with SJS, which is accompanied by the involvement of all body systems and defines the disease prognosis.