Introduction & Objectives: The COVID-19 pandemic has made adjustments both in the general life of people and in the medical practice of doctors of many specialties. In addition, doctors - dermatovenerologists at daily appointments increasingly consult users with drug-induced rashes that occurred after treatment of COVID-19. Medicinal lesions of the skin with a viral coronavirus infection are necessarily associated with a large number of drugs of various pharmacological groups prescribed to the patient, which, interacting, can have a toxic effect on human protection. One of the most important manifestations of the toxic effect of drugs on the human body is toxic epidermal necrolysis (TEN).
Purpose The research method was to analyze the anamnestic data from TEN and characterize the amino acid composition of the blood serum of such patients with damage to more than 50% of the skin area.
Materials & Methods: 6 used TENs were under our observation, during periods of various diseases (initial, acute) that had undergone COVID-19, the area of the affected skin was determined by the rule of “nines”, the amino acid composition of blood serum was determined by the method of thin-layer two-dimensional chromatography.
In order to determine the indicators of carbohydrate metabolism and their influence on the course of superficial candidiasis, 97 patients with different severity of this disease were examined.The study of carbohydrate metabolism included the determination of fasting blood sugar level to detect the overt diabetes and glucose tolerance test (with the load of 75 g of glucose).The impaired glucose tolerance was detectedin 36 patients, so their levels of
glycosylated hemoglobin and fructosamine wereadditionallydetermined.HbA1c level was determined in whole blood by ion exchange chromatography. Fructosamine was measured by kinetic colorimetric method in both serum and plasma.Blood sampling was performed on an empty stomach from the cubital vein. The studies were carried out immediately after sampling.The Sentinel CH test system from Intero (Italy) and a spectrophotometer with a 405-425 nm filterwere used for the research.
Results: The research showed that in the group of patients with candidal lesions, there is a direct dependence of HbA1c and fructosamine on the severity of the disease.In patients with minimal and moderate candidal lesions, an increase in HbA1c and fructosamine indicators was observed compared to similar indicators in the control group by 1.54 and 1.21 times respectively. In patients with significant candidal lesions and relapses, the concentration of HbA1cincreased by 2.59 timesand of fructosamineby 2.26 times in relation to the indicators of the control group.
Nowadays dermatologist’s arsenal contains numerous pharmacological agents with high efficiency, but achieving the desired results in acne therapy is still not the easiest problem. The aim - to study the modern possibilities of medical and cosmetological correction of acne manifestations based on the analysis of foreign and domestic sources. We conducted a review with further analysis of foreign and domestic sources, domestic, European and American recommendations for the treatment of acne. Publications were searched through the National Center of Biotechnology Information, PubMed, StudMed and GoogleBooks resources.
Today, the use of platelet-rich plasma is increasing in clinical practice in various fields of medicine. The plasma therapy is used by dermatologists, dentists, gynecologists, traumatologists and many other specialists in daily practice. Platelet-rich plasma is actively used in dermatology after its clinical effectiveness has been established. The plasma therapy method alone, as well as in combination with other methods of treatment, has shown advantages in certain skin diseases: androgenetic alopecia, alopecia areata, chronic vitiligo, melasma, inflammatory nail disorders, psoriasis, acne, post-acne and seborrheic dermatitis. Platelet-rich plasma can suppress cytokine release and limit inflammation by interacting with macrophages, improving tissue healing and regeneration, promoting the formation of new capillaries and accelerating epithelialization. Plasma platelets also play an important role in the host’s defense mechanism at the wound site by producing signaling proteins that attract macrophages. Blood plasma also has antimicrobial activity against Escherichia coli, Staphilococcus aureus, Candida albicans and Cryptococcus neoformans.
Однією з нагальних проблем сучасної дерматології є значне поширення захворювань шкіри та слизових оболонок, спричинених дріжджоподібними грибами. За даними ВООЗ, від мікозу потерпає понад чверть населення Землі, а грибкові ураження спричиняють виникнення різноманітних захворювань шкіри та слизових оболонок людини, що здебільшого мають тяжкий та тривалий перебіг і характеризуються частими рецидивами. В Україні останніми роками також спостерігають значне збільшення кількості випадків захворювання на мікози, наявна тенденція до розвитку ускладнених форм, що призводить до тривалої втрати працездатності. За результатами наших досліджень встановлено прямий кореляційний зв’язок між ступенем тяж- кості кандидозу та рівнем глікозильованого гемоглобіну і фруктозаміну. Виявлення кореляційних закономірностей є важливим елементом розробки комплексного патогенетично обґрунтованого лікування пацієнтів з кандидозними ураженнями шкіри та слизових оболонок.