Following the interaction of 2-chloro-N-(5-aryl-1,3,4-oxadiazole-2-yl) acetamides 1a-b with ammonium thiocyanate in dry acetone, the 5-unsubstituted 2-imino-4-thiazolidinones 4a-b have been synthesized. Compounds 4a-b were subsequently utilized in Knoevenagel condensation with aromatic aldehydes or isatin derivatives to synthesize the series of 5-arylidene/isatinylidene substituted 2-(1,3,4-oxadiazol-2-yl)imino-4-thiazolidinones 5a-h and 6a-d. The structures of target compounds were confirmed by using 1H NMR spectroscopy and elemental analysis. Evaluation of anti-cancer activity in
vitro for the synthesized compounds was performed following the National Cancer Institute protocol against leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancer cell lines. As a result, the most active compound 5a, namely 2-[5-(4-chlorophenyl)-[1,3,4]oxadiazol-2-ylimino]-5-(4-methoxybenzylidene)thiazolidin-4-one was found to be a highly efficient anti-tumor candidate with average logGI50 and logTGI values of -5.19 and -4.09, respectively
Silicon-containing (Si-containing) polishing paste has been tested clinically in patients with chronic generalized periodontitis, I-st degree of severity. All patients have been examined for the presence of supra- and sub-gingival calculus and bleeding on probing on a six- month-testing time and within one year after conducting the professional hygienic procedures. It has been revealed that the proposed Si-containing polishing paste proved to be effective in the maintenance of gingival health in the lapse of time from 1 to 12 months after treatment. The majority of patients showed neither dental deposits nor bleeding on probing up in the interval from 1 to 12 months after dental scaling and polishing with Si-containing polishing paste.
. One of the problems in standardizing Bioadhesive dental film (BDF) produced by the solvent casting method, is the use of a Casting Mould with clearly set geometrical parameters of 10.0 x 60.0 mm, when using a set volume of polymer gel. Many scientific studies dealing with the preparation of polymeric medical film fail to describe the technological equipment necessary for the manufacture of BDF (bio dental films) using the solvent casting method on a flat surface.
During the scientific development of this process, three types of devices were designed, tested and patented, these being a Casting Mould, and Perforating and Cutting Devices to be applied in the production of dental BDF using the solvent casting method.
The Casting Mould is made of a neutral glass and has the dimensions of 60 x 400 mm which allows the tie production of dental films of a standardized size using the solvent casting method. The Perforating Device results in improved perforated BDF in the process of its production. Meanwhile the Cutting Device allows the uniform distribution and cutting of the polymer film into dozaged strips with accurately specified geometrical dimensions of 10.0 x 60.0 mm.