Tlre possible role of viral persistence as an epigenetic factor in the development of
psoriasis is discussed when a specific antigen (virus, especially type 1,2 (HSV 1,2)) is considered as a trigger factor
for direct or indirect action on immunocompetent cells.
The purposeTo evaluate the peculiarities of blood lyrnphocytes phenotyping in patients with psoriasis and
activated chronic Herpes slmplex virus infection compared to patients with psoriasis, activated chronic Herpes
virus infection, and healthy persons during treatment
Toxic epidermal necrolysis (TEN) is one of the most severe reactions of the body to
the action of various xenobiotics with necrosis of the epidermis, mucous membranes and damage to internal
organs, which is accompanied by profound disorders of hemodynamics and homeostasis, often leading to death.
A wide range of bioregulatory effects of nitric oxide, in particular, participation in the development and course of
allergic inflammation (cytotoxic, immunocomplex reactions), suggest the participation of nitric oxide in the
pathogenesis of TEN
Today, the use of platelet-rich plasma is increasing in clinical practice in various fields of medicine. The plasma therapy is used by dermatologists, dentists, gynecologists, traumatologists and many other specialists in daily practice. Currently, there is a large number of patients seeking medical help with seborrheic dermatitis. However, the complexity of the pathogenesis of seborrheic dermatitis and its sensitivity to medications require from the dermatologist a differential approach in choosing the local therapy.
Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide.The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization. The results of conducted clinical, morphological and immunohistochemical investigations enable to consider importance of neoangiogenesis processes in pathogenesis of this dermatosis and need in elaboration of therapeutic measures with direct influence on this aspect of pathogenesis.
Останніми роками дерматологи все частіше звертають увагу на проблему взаємозв’язку захворювань шкіри із вживанням лікарських препаратів. Під нашим спостереженням перебували 64 хворих із ТАД, які проявлялися багатоформною ексудативною еритемою, синдромом Стівенса—Джонсона та токсичним епідермальним некролізом. Лікувальна тактика хворих на токсико-алергійні дерматози має ґрунтуватись на урахуванні чин- ників, що призводять до розвитку цих станів.