The researchers of the Truskavetsian Scientific School of Balneology have demonstrated that effect of balneotherapy at the Truskavets’ Spa on the physical working capacity of both healthy rats and different categories of patients is ambiguous. It is shown that various variants of actotropic effects are accompanied by characteristic changes in a number of body parameters. The purpose of this study was to identify neuro- endocrine, hemodynamic and metabolic accompaniments of actotropic effects of balneotherapy in men with maladaptation. Material and methods. The object of observation were 34 men (aged 23÷70 years) with maladaptation against the background of chronic pyelonephtis in remission phase, who came for rehabilitation at the Truskavets' Spa. The object of study: PWC, hemodynamics, HRV, EEG, adaptation hormones, blood and urine metabolites. The survey was conducted twice: on admission and after 7-10 dais of rehabilitation. Results. The analysis of individual changes revealed that balneotherapy in 18 patients did not significantly affect the level of fitness. In 9 patients balneotherapy caused an increase in PWC150 (direct difference: 0.57±0.12 W/kg) while in the other 9 patients the level of fitness decreased (direct difference: -0.42±0.03 W/kg). Discriminant analysis revealed 24 variables as characteristic accompaniment of the three variants of actotropic effects of balneotherapy. Among them, 2 are hemodynamic, 13 are neural, which reflect the entropy of EEG and HRV as well as delta-, theta- and beta-rhythms, 2 are endocrine, and 7 are metabolic. Classification accuracy is 100%. Conclusion. The multivariate actotropic effects of balneofactors are due to their multivariate effects on neuro- endocrine regulation and metabolism, which, apparently, is determined by the peculiarities of the individual reactivity of the body.

Ergometric physical working capacity (PWC) testing has a long tradition in occupational medicine for assessing whether a sufficiently high level of physical performance for coping with the daily work requirements is given. Physical performance and stress resistance of the body are considered one of the main objects of influence of adaptogens. The stress-limiting effect of bioactive Naftussya water known. Data on the influence of Naftussya on the muscular performance are ambiguous. We set ourselves the goal of comparing balneotherapy-induced individual changes in PWC with changes in some parameters of the nervous and immune systems, as well as erythron, hemostasis, and metabolism. Material and methods. The object of observation were 19 men and 3 women (age 26÷61 years, body weight 78÷100 kg) with urate urolithiasis and chronic pyelonephritis. The survey was conducted twice: on admission and after two weeks of rehabilitation at the Truskavets’ Spa. Registered PWC150, parameters of HRV, EEG, immunity, phagocytosis, erythron, hemostasis and metabolism. Results. The analysis of individual changes revealed that in 45,5% patients reduced fitness was completely normalized, however, in 54,5% patients, the normal level of fitness fell to the lower zone of the norm. Discriminant analysis revealed 5 EEG parameters, VLF band HRV as well as plasma alanine aminotransferase and bactericidal capacity of monocytes of blood, the changes of which are characteristic (classification accuracy 100%) for alternative variants of actotropic effects of balneotherapy. Conclusion. The alternative response of fitness to balneofactors occurs within the framework of the functional-metabolic continuum and the neuro-immune complex. A decrease in fitness to the lower normal zone is accompanied by the normalization of the reduced bactericidal capacity of blood monocytes, so we interpret this decrease as a “physiological payment” for it.