In recent decades, the role of hydrogen sulfide (H2S), a gas mediator and signaling agent, has been studied in the regulation of intercellular signaling and intracellular signal transduction pathways with various physiological and pathophysiological effects in cells and tissues. These cellular pathways are responsible for changes in metabolism, epigenetic, and cellular behavior. There are enzymatic and non-enzymatic pathways of endogenous hydrogen sulfide biosynthesis. Numerous studies have shown the diverse effects of H2S on the physiological processes of neurotransmission in the brain, vascular smooth muscle relaxation in synergy with nitric oxide (NO), apoptosis, autophagy, angiogenesis, aging, inflammation, redox system, manifestations of oxidative stress, protein, as well as bioenergetic effects and systemic bioregulatory effects, including ANS. Recently, it was shown that H2S signaling is often dysregulated in different dysfunctions. The effect of H2S on insulin secretion and protection of the heart, kidneys, and brain from ischemic damage, and hypoxia is known. The availability of H2S as a bioregulator has led to changes in cytoprotection, scavenger’s function, and antiinflammatory activities in the digestive system, as well as it could be a molecular target for the creating new safe hybrid compounds, esp., H2S-realized nonsteroidal anti-inflammatory drugs. Our recent research has shown a cytoprotective effect on the mucous membrane of the esophagus and stomach. Thiosulfate sulfurtransferase (TST, EC 2.8.1.1)-derived H2S plays an important role in maintaining redox balance but its effects on mesenteric integrity in aspects of age-related changes and during stress response or high-carbohydrate diet are still limited.
2023 marks the 125th anniversary of the foundation of the Medical Commission of the Shevchenko Scientific Society’s publication, whose successor today is the journal Proceedings of the Shevchenko Scientific Society. Medical Sciences (Medical Sciences, ISSN 2708-8634; eISSN 2708–8642). Dr Eugen Ozarkevych, the founder and later the Chair of the Shevchenko Scientific Society’s Medical Commission in Lviv, initiated the publication of the scientific and practical journal “Medical Collection” («Лікарський збірник») in 1898. The journal’s primary purpose was to promulgate scientific achievements in the field of medicine in Ukrainian and to create Ukrainian medical terminology. This format allowed the reader to review scientific achievements in fundamental and clinical medicine, current medical problems, and new methods to in the prevention, diagnosis and treatment of various diseases. Ukrainian professional medical terminology was presented in this journal for the first time. Throughout its existence, this oldest medical journal, Medical Sciences, remains faithful to its historical multidisciplinary orientation. During the information and Russian war on the territory of Ukraine, Medical Sciences serves as a national heritage of Ukraine. It is recognized by international partners and indexed in scientometric bibliographic databases such as Scopus, Copernicus, Directory of Open Access Journals (DOAJ), and Google Scholar. As an Open Access Journal, it is read in 155 countries of the world.
Keywords: Shevchenko Scientific Society, Medical Commission of the Shevchenko Scientific Society, Medical Bulletin, Proceedings of the Shevchenko Scientific Society. Medical Collection. Medicine and Biology. New Series, Proceedings of the Shevchenko Scientific Society. Medical Sciences.