Today, the use of platelet-rich plasma is increasing in clinical practice in various fields of medicine. The
plasma therapy is used by dermatologists, dentists, gynecologists, traumatologists and many other
specialists in daily practice.
Platelet-rich plasma is actively used in dermatology after its clinical effectiveness has been established.
The plasma therapy method alone, as well as in combination with other methods of treatment, has
shown advantages in certain skin diseases: androgenetic alopecia, alopecia areata, chronic vitiligo,
melasma, inflammatory nail disorders, psoriasis, acne, post-acne and seborrheic dermatitis.
Platelet-rich plasma can suppress cytokine release and limit inflammation by interacting with
macrophages, improving tissue healing and regeneration, promoting the formation of new capillaries
and accelerating epithelialization.
Plasma platelets also play an important role in the host's defense mechanism at the wound site by
producing signaling proteins that attract macrophages. Blood plasma also has antimicrobial activity
against Escherichia coli, Staphilococcus aureus, Candida albicans and Cryptococcus neoformans.
Currently, there is a large number of patients seeking medical help with seborrheic dermatitis.
However, the complexity of the pathogenesis of seborrheic dermatitis and its sensitivity to medications
require from the dermatologist a differential approach in choosing the local therapy.

Introduction In recent years, dermatologists and cosmetologists have increasingly paid attention to the
problem of the relationship between skin diseases and the organs of the gastrointestinal tract (GI).
Numerous clinical and microbiological studies confirm the connection between gastrointestinal
pathology and intestinal dysbacteriosis with inflammatory skin diseases. The purpose of our study was to
investigate the influence of the intestinal microbiocenosis on the severity of acne (AC)

The relevance of the problem of urticaria is generally recognized. The chronic infection foci, gastrointestinal diseases, diabetes mellitus, malignant neoplasms, etc. are among the factors that initiate the manifestation of the disease. However, the studies devoted to evaluation of the endocrine glands in such patients remain unaddressed. Although it is known that, in particular, the thyroid gland takes an active part in the development of allergic dermatoses. Objective: To study the thyroid hormone balance in patients with chronic idiopathic urticaria.