A congenital anomaly of coronary vessels in the form of myocardial muscle bridges (MBs) is most commonly located in the left coronary artery’s system, specifically in the middle segment of the anterior interventricular branch. Typically considered a benign condition, it can be asymptomatic. However, the presence of MBs has been associated with various clinical manifestations, some of which pose threats to the life and health of patients, unresolved issues that include medical management tactics for handling such patients, specifics of assisting during complications and determining the need for intervention in asymptomatic cases. This article presents contemporary perspectives on the clinic, diagnosis, and treatment of symptomatic patients with MBs, considering concomitant myocardial ischemia. We presented a case of a 41-year-old male with the myocardial bridge in the left coronary artery characterized by a high degree of systolic compression of the vessel, widespread exercise-induced subendocardial ischemia with abdominal pain and WPW phenomenon.