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Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. At the present stage, psoriasis is considered to be a systemic disease that affects not only skin but also joints of patients and is accompanied by possible development of typical comorbid states (cardiovascular pathology, chronic inflammatory intestinal canal diseases, and metabolic syndrome).
Objective — to improve the diagnosis of arthropathic psoriasis (AP) taking into account some of the most important indicators of the immune-endocrine system and features of the disease course to specify their role in the pathogenesis of the disease and to develop the system of integrated therapy.
Materials and methods. A total of 178 AP patients have been systematically examined that had varying severity of process development, generalization and intensity of skin and osseous-articular apparatus damage, the presence of associated pathology. Additional instrumental studies, determination of biochemical, serological parameters and an assessment of stress-induced immune-endocrine system have been conducted in AP patients. The content of trigger cytokines (IL-1, IL-8, IL-17, IL-22) in blood serum, stress hormones (ACTH, cortisol), cellular and humoral immunity condition (CD3+, CD4+, CD8+, CD16+, CD22+, IgM and IgG levels) have been studied.
Results and discussion. The clinical course and characteristic features of AP instrumental tests are extremely versatile. Regardless of the disease duration period, we have detected in blood serum of AP patients probable decrease in parameters of cellular immunity (CD3+, CD4+, CD8+-fraction of T-lymphocytes, CD22+-fraction of B-lymphocytes) and compensatory increase in CD16+ of T-cells, decrease in parameters of cytokines (IL-1, IL-8, IL- 17, IL-22), stress hormones (cortisol, immunoglobulins IgM, IgG, and CIC), which indicates tension of their stress-induced mechanisms even despite occasional clinical stabilization of skin and articular process. We have offered and tested regiments to treat AP patients, which involve differential application within the integrated therapy of nonsteroidal anti-inflammatory medications (etoricoxib 30—60 mg 1 time daily/diclofenac 75 mg daily), diseasemodifying medications (sulfasalazine ЕН from 500 mg to 2 g daily/methotrexate 7.5—10 mg/week), lyophilised dialysate of leukocytes.
Conclusions. The analysis of specific features of the AP clinical course and data of integrated studies allows identifying the probability of manifestation or persistence of the pathological psoriatic articular process. The improvement of AP patients diagnostics taking into account some of the most important indicators of the immune-endocrine system and specifics of the disease course contributed to the improved therapy and mended quality of life of patients.

Introduction & Objectives: The COVID-19 pandemic has made adjustments both in the general life of people and in the medical practice of doctors of many specialties. In addition, doctors - dermatovenerologists at daily appointments increasingly consult users with drug-induced rashes that occurred after treatment of COVID-19. Medicinal lesions of the skin with a viral coronavirus infection are necessarily associated with a large number of drugs of various pharmacological groups prescribed to the patient, which, interacting, can have a toxic effect on human protection. One of the most important manifestations of the toxic effect of drugs on the human body is toxic epidermal necrolysis (TEN).
Purpose The research method was to analyze the anamnestic data from TEN and characterize the amino acid composition of the blood serum of such patients with damage to more than 50% of the skin area.
Materials & Methods: 6 used TENs were under our observation, during periods of various diseases (initial, acute) that had undergone COVID-19, the area of the affected skin was determined by the rule of “nines”, the amino acid composition of blood serum was determined by the method of thin-layer two-dimensional chromatography.

In order to determine the indicators of carbohydrate metabolism and their influence on the course of superficial candidiasis, 97 patients with different severity of this disease were examined.The study of carbohydrate metabolism included the determination of fasting blood sugar level to detect the overt diabetes and glucose tolerance test (with the load of 75 g of glucose).The impaired glucose tolerance was detectedin 36 patients, so their levels of
glycosylated hemoglobin and fructosamine wereadditionallydetermined.HbA1c level was determined in whole blood by ion exchange chromatography. Fructosamine was measured by kinetic colorimetric method in both serum and plasma.Blood sampling was performed on an empty stomach from the cubital vein. The studies were carried out immediately after sampling.The Sentinel CH test system from Intero (Italy) and a spectrophotometer with a 405-425 nm filterwere used for the research.
Results: The research showed that in the group of patients with candidal lesions, there is a direct dependence of HbA1c and fructosamine on the severity of the disease.In patients with minimal and moderate candidal lesions, an increase in HbA1c and fructosamine indicators was observed compared to similar indicators in the control group by 1.54 and 1.21 times respectively. In patients with significant candidal lesions and relapses, the concentration of HbA1cincreased by 2.59 timesand of fructosamineby 2.26 times in relation to the indicators of the control group.

Psoriasis is related to the systemic diseases characterised by a complex of mutually conditioned pathogenetic links (immune, neuro-endocrine, infectious, etc.). Microbiocenosis of both healthy and pathologically altered skin can serve thepoint to assess the health of macroorganism. In chronic dermatoses a qualitative and quantitative change in skin microbial associations is observed. Changes in macroorganismare reflected in disorders of microbial landscape of all skin topographic zones. It should be noted, that the study of microbial skin flora in psoriatic patients is episodic and unstructured. Despite loads of suggested methods and therapeutic means used to treat psoriatic patients, their efficacy remains not high due to the uncertainty of aetiology, disease pathogenesis multi-factority and polymorphism of clinical manifestations. The purpose of our study was to study changes in microbial flora of psoriatic patients skin under NBUVB application

Nowadays dermatologist’s arsenal contains numerous pharmacological agents with high efficiency, but achieving the desired results in acne therapy is still not the easiest problem. The aim - to study the modern possibilities of medical and cosmetological correction of acne manifestations based on the analysis of foreign and domestic sources. We conducted a review with further analysis of foreign and domestic sources, domestic, European and American recommendations for the treatment of acne. Publications were searched through the National Center of Biotechnology Information, PubMed, StudMed and GoogleBooks resources.