Background. The impact of the standard balneotherapeutic complex at Truskavets' Spa on physical performance in both rats and resort patients yielded mixed results. Previous research has indicated that the phytoadaptogen “Balm Truskavets” can mitigate the negative effects of Naftussya bioactive water on dynamic muscle performance in healthy rats and patients with post-radiation encephalopathy. This study aims to evaluate the potential of this phytocomposition to prevent unfavorable actotropic effects of Truskavets’ Spa balneofactors on gastroenterologic patients. Material and methods. The study observed 40 former female athletes (aged 30÷76 years, body weight 55÷98 kg) with chronic cholecystitis in remission phase, undergoing rehabilitation at Truskavets' Spa. Parameters including PWC150, adaptation hormone levels, HRV, EEG, immunity, metabolism and gas discharge visualization (GDV) were recorded. Members of the control group received for two weeks standard balneotherapy: drinking of Naftussya bioactive water, application of Ozokerite, baths with mineral water, therapeutic physical education. Members of the main group additionally received a phytoadaptogen. Results. The analysis of individual changes revealed that normal levels of PWC in control group fell to the lower zone of the norm. Phytoadaptogen prevents PWC decrease. This is accompanied by the prevention of both a decrease in power spectral density (PSD) T4-θ EEG and VLF HRV, leukocytes level as well as area and symmetry of GDV, as well as an increase in vagal tone and entropy of HRV as well as a rightward shift in the symmetry of the virtual first Chakra of GDV. In addition, phytoadaptogen reverses balneotherapy-induced moderate decrease in the frequency of α-rhythm, PSD O1-β, sympathetic tone, serum levels of catecholamines, testosterone and IgG, activity of Na,K-ATPase of erythrocyte shadows as well as Energy of the first, third and fourth virtual Chakras. Phytoadaptogen potentiates the reduction of PSD P4-β, IgM and cholesterol as well as initiates the reduction of δ-rhythm variability, PSD of α-rhythm in C3, C4, P4 and Fp2 loci, entropy in F4 locus as well as serum potassium while increasing in serum cortisol and calcitonin, blood B-lymphocytes levels as well as PSD Fp2-δ. Conclusion. The phytoadaptogen "Balm Truskavets'" prevents the adverse effect of the standard balneotherapeutic complex of the Truskavets’ Spa on PWC by, apparently, its neuro-endocrine effects.