Humic substances are a group of macromolecular compounds that are non-living organisms, but are products of plant transformation, animal and microbial residues in natural conditions. The studies revealed that humic substances extracted from sapropel have a wide range of biological properties: antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, membrane and hepatoprotective. They are capable to increase the activity of metabolic processes in the body and normalize the leukocyte blood formula in leukemia as well. The objective of our work was to determine the presence of photoprotective activity of products with different sapropel extract contents on the model of acute photodynamic skin inflammation in rats. Investigation of anti-inflammatory activity of sapropel extract gel samples was carried out on the model of ultraviolet erythema in rats, which was caused by the irradiator "Promin" ZEMI" with a mercury-quartz lamp of DRT 125-1 type. Complete healing of ultraviolet erythema was observed in the group of animals treated with the sapropel extract gel in concentration of 15% and 10%, respectively on the 6th and 7th days after ultraviolet - irradiation. It should be noted that according to the indices of anti-inflammatory activity and skinfold thickness, the comparison product was significantly weaker to the gels with the sapropel extract. The gel with the sapropel extract in 15% concentration showed the best results. Key words: humic substances, sapropel extract, gel, anti-inflammatory activity, UV- erythema