The increase in the frequency of toxic-allergic diseases is the result of an increase in the number of drugs on the pharmaceutical market, which leads to mass self-medication of the population. Most often, patients seek medical help after self-medication, using drugs of various pharmacological groups. Stevens-Johnson syndrome is the most common side effect of the drug.

A high incidence of acne, tendency to a chronic course with the formation of resistance to treatment and frequent development of deep forms determine the important medical problem. In the examined patients with acne, the qualitative and quantitative changes in the parameters of microbiocenosis of the skin and large intestine were determined, which depend on the clinical course of dermatosis, which indicates the need for additional examination of such patients in order to prescribe a pathogenetically substantiated therapy.

Taking into account actuality of psoriasis morbidity problem, specialists point out differentiated individual approach to diagnostic and therapeutic stages as a key aspect in the management of patients. Investigation of main points of etiopathogenesis and elaboration of target influence on its key aspects will enable to achieve a set goal. Both rapid epidermal proliferation and dermal inflammatory infiltration are accompanied by numerous formations of new blood vessels, which start during the early changes of psoriasis and vanish after skin lesion clearance. These observations highlighted that angiogenesis is the chief distinguishing feature during the pathogenesis of psoriasis. Among non-specific stimulants of angiogenesis, matrix metalloproteinase (MMP) should be singled out, which is a group of matrix-destructing enzymes, the source of which are fibroblasts, macrophages, neutrophils and other cells that play an important role in tissue remodelling, including neoangiogenesis processes.

ABSTRACT

The aim: The objective of our work was to improve the diagnostics of common chronic dermatoses (acne, psoriasis, АР) taking into account some indicators of the immune system and features of the disease course to specify their role in pathogenesis of these disease.
Materials and methods: A total of 114 patients with acne and 128 patients with psoriasis were observed.
Results: Regardless of the disease duration period, we have detected in blood serum of psoriasis рatients probable changes in concentrations of stress-response mediators (decreased parameters of cellular immunity (CD3+, CD3+CD4+, CD3+CD8+ of T-lymphocytes, CD22+ fraction of B-lymphocytes and compensatory increased CD16+ of T-cells, cytokines – IL-1β, IL-8, IL- 17, IL-22, immunoglobulins IgM, IgG, and CIC), which indicate tension of their stress-induced mechanisms even despite occasional clinical stabilization of skin and articular process. Consequently, most of the patients with acne had varying degrees of changes in rates of systemic immunity. The most significant changes in rates of systemic immunity with the depletion of T-cell immunity were found in patients with papular-pustular and pustular acne, and still more significant – in patients with acne conglobate.

Conclusions: In patients with acne and psoriasis, changes in systemic immunity indexes that indicate the formation of secondary immunodeficiency state T-cell link, amid an adequate humoral immunity have been found. Relationship between the causes of changes of systemic immunity has been established.

KEY WORDS: acne, psoriasis, clinical course, immunity, diagnostic