The hypotensive effect of endotrabeculectomy as a stand-alone glaucoma operation and deep sclerectomy in combination with endotrabeculectomy in patients with primary open-angle glaucoma was compared. We observed 35 patients (35 eyes) with primary open-angle glaucoma. In the first group (23 patients, 23 eyes) endotrabeculectomy as stand-alone operation was performed, in the second group (12 patients, 12 eyes) deep sclerectomy in combination with endotrabeculectomy was performed. When comparing the intraocular pressure, it was found that the difference between preoperative and postoperative intraocular pressure was significant lower up to 9 months in both groups (p < 0.05), but the hypotensive effect in the second group was slightly more expressed - 6.7 and 7.83 mm Hg in accordance. The number of glaucoma medications in the first group decreased by 0.60, while in the second group - by 2.58 (p < 0.05). Thus, hypotensive effect of combined surgery outweighs the effect of stand-alone endotrabeculectomy