Background: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ₁₀ is the most common form of CoQ in humans. A deficiency of CoQ₁₀ occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, certain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsible for CoQ₁₀ biosynthesis and, thus, lead to CoQ₁₀ deficiency.

Objectives: This article aims to evaluate the cumulative studies and insights on the topic of CoQ₁₀ functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle.

Results: Although supplementation with CoQ₁₀ offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associated muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used.

Conclusion: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ₁₀ in a range of health conditions and diseases.

Introduction: The treatment of most diseases in dentistry is related to the local application of antiseptic drugs that regulate the microbiocenosis in the oral cavity. The study of pharmacodynamic and kinetic parameters of the release of active pharmaceutical ingredients (APIs) from the dosage form (DF) is an important task. In this study, we tried to evaluate the release of APIs from developed dental medicinal films (DMF) produced on a polymeric basis. Methods: To confirm the antimicrobial activity of the three developed DMF with amizon, decamethoxine and chlorhexidine digluconate, a statistical analysis and mathematical processing of the research results were carried out. Results: Statistical processing made it possible to organize the results of our earlier studies, in which the concentrations of three APIs (amizon, decamethoxine, and chlorhexidine digluconate) were determined during their diffusion from the polymer base of the DMF to the aqueous dispersion medium (0.9% sodium chloride solution). Due to performed statistical calculations, regarding the reliability of APIs release, it was determined that the time duration of complete release of the three active substances from the polymer base was different, which will ultimately affect the duration of the pharmacological effect of the APIs in the patient's body. Conclusion: In the manufacture of DMF on a polymeric base of hydrophilic type, it is necessary to take into account the release time of each API, according to the composition of the polymeric coatings.

 ABSTRACT

Aim: The purpose of this study is to assess the impact of occupational hygiene procedures for microbiological and cytological contents of periodontal pockets. Material and Methods: Cytological and microbiological content of the periodontal pockets before treatment and after professional hygiene procedures including scaling with hand instruments and root cementum polishing have been investigated in patients with periodontitis.

Results: According to obtained data it can be resumed that in periodontitis patients with the depth of pockets 3-5,5 mm before professional hygiene all the pockets contain great number of Cocci, Spirochetes, Candida Albicans, Flagellated rods and Protozoa species. It was proved by revealing of small amount of Polymorphonuclear leukocytes with active phagocytosis. After scaling and planing of the roots, a decrease in the number of Protozoa and Candida Albicans was observed in 97% and 72% of the investigated cells, respectively.

Conclusions: Cytological and microbiological content of periodontal pockets before treatment and after professional hygiene procedures including scaling and root planning testify to the level of local protective mechanisms, especially process of phagocytosis and virulence of microbial species in periodontal pockets. KEY WORDS: periodontitis, scaling, microbiological, cytological investigation 

 The pathology of the hepatobiliary system significantly affects the state of the organs of the oral cavity. A clinical and index study of the state of periodontal tissues in 122 patients was conducted, which showed the prevalence of periodontal disease in patients with chronic acalculous cholecystitis. The examined patients were divided into groups depending on the treatment method, and the result was evaluated before treatment, directly after treatment and 6 months following treatment. Antidysbiotic hepatoprotector and 2% thiotriazolin ointment were included in the combination therapy. Studies have shown that patients with hepatobiliary pathology have increased likelihood of periodontal diseases, and after treatment, periodontal indicators and the hygiene index are significantly reduced, especially in the group where the proposed scheme was used, and the long-term results were stable for 6 months. 

The influence of food products on the development of dental caries was investigated with the help of statistical methods.