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Psoriasis is a life-long chronic autoimmune disease characterized by thick scaly skin lesions and often associated with severe arthritis. At the present stage, psoriasis is considered to be a systemic disease that affects not only skin but also joints of patients and is accompanied by possible development of typical comorbid states (cardiovascular pathology, chronic inflammatory intestinal canal diseases, and metabolic syndrome).
Objective — to improve the diagnosis of arthropathic psoriasis (AP) taking into account some of the most important indicators of the immune-endocrine system and features of the disease course to specify their role in the pathogenesis of the disease and to develop the system of integrated therapy.
Materials and methods. A total of 178 AP patients have been systematically examined that had varying severity of process development, generalization and intensity of skin and osseous-articular apparatus damage, the presence of associated pathology. Additional instrumental studies, determination of biochemical, serological parameters and an assessment of stress-induced immune-endocrine system have been conducted in AP patients. The content of trigger cytokines (IL-1, IL-8, IL-17, IL-22) in blood serum, stress hormones (ACTH, cortisol), cellular and humoral immunity condition (CD3+, CD4+, CD8+, CD16+, CD22+, IgM and IgG levels) have been studied.
Results and discussion. The clinical course and characteristic features of AP instrumental tests are extremely versatile. Regardless of the disease duration period, we have detected in blood serum of AP patients probable decrease in parameters of cellular immunity (CD3+, CD4+, CD8+-fraction of T-lymphocytes, CD22+-fraction of B-lymphocytes) and compensatory increase in CD16+ of T-cells, decrease in parameters of cytokines (IL-1, IL-8, IL- 17, IL-22), stress hormones (cortisol, immunoglobulins IgM, IgG, and CIC), which indicates tension of their stress-induced mechanisms even despite occasional clinical stabilization of skin and articular process. We have offered and tested regiments to treat AP patients, which involve differential application within the integrated therapy of nonsteroidal anti-inflammatory medications (etoricoxib 30—60 mg 1 time daily/diclofenac 75 mg daily), diseasemodifying medications (sulfasalazine ЕН from 500 mg to 2 g daily/methotrexate 7.5—10 mg/week), lyophilised dialysate of leukocytes.
Conclusions. The analysis of specific features of the AP clinical course and data of integrated studies allows identifying the probability of manifestation or persistence of the pathological psoriatic articular process. The improvement of AP patients diagnostics taking into account some of the most important indicators of the immune-endocrine system and specifics of the disease course contributed to the improved therapy and mended quality of life of patients.

Psoriasis affects about2To of population In 30-40% of occurrences arthropathic
psoriasis (AP) is diagnosed and it leads to 11-19% of disability cases development. The article analyses features of
anamnesis, clinical, instrumental and laboratory tests related to arthropathic psoriasis, considers the relationship of
probable mechanisms of disease aggravation and progression with the definition of a treatment method
influencing the dynamics of a disease course.
The objective of our work was to improve the diagnostics of AP patients taking into account some indicators of
the inrmune-epdocrine system and features of the disease course to specify their role in AP pathogenests and to
develop the system of integrated therapy of patients whose locomotor system is affected due to psoriasis

Tlre possible role of viral persistence as an epigenetic factor in the development of
psoriasis is discussed when a specific antigen (virus, especially type 1,2 (HSV 1,2)) is considered as a trigger factor
for direct or indirect action on immunocompetent cells.
The purposeTo evaluate the peculiarities of blood lyrnphocytes phenotyping in patients with psoriasis and
activated chronic Herpes slmplex virus infection compared to patients with psoriasis, activated chronic Herpes
virus infection, and healthy persons during treatment

BACKGROUND: A decrease in the incidence of syphilis has been observed in the world and in Ukraine in recent years. At the same time, an increase in cases of neurosyphilis is recorded. Diagnosis of neurosyphilis is quite difficult and based on the correct interpretation of the complex of various diagnostic tests.
OBJECTIVES: The paper is aimed to determine diagnostic potential of treponemal tests (TTs) and evaluate effectiveness of Treponema pallidum immunoblot (TPI) while research on cerebrospinal fluid (CSF) in differential diagnosis of neurosyphilis.
MATERIALS AND METHODS: The research object was CSF of patients with late forms of syphilis. The regulated serological and immunological methods in accordance with current guidelines and orders of the Ministry of Healthcare of Ukraine were used for laboratory diagnosis of neurosyphilis: Enzyme immunoassays (EIA), fluorescent treponemal antibody (FTA), T. pallidum hemagglutination assay (TPHA), and TPI.
RESULTS: Effectiveness of TTs in the diagnosis of neurosyphilis while research on 23 samples of CSF was carried out by the following methods: EIA (Immunoglobulin [Ig]M + IgG), FTA, andTPHA. The above-mentioned TTs used in serological diagnosis of CSF do not always meet the problem of confirming neurosyphilis diagnosis. According to these investigations, both positive and false positive results were obtained. In order to verify the diagnosis, a study on positive and false positive samples of CSF by TPI method was carried out. Positive results were obtained in 13 samples with the established duration of the disease.
CONCLUSIONS: TPI is an optimal treponemal immunological method of examination of CSF to diagnose neurosyphilis with a high degree of reliability. The use of TPI while research on CSF makes it possible to verify the diagnosis of neurosyphilis by differentiated detection of antibodies to the most immunogenic antigens of T. pallidum eliminating the subjective factor of the reaction and simplifies diagnostic procedure.

The relevance of the problem of urticaria is generally recognized. The chronic infection foci, gastrointestinal diseases, diabetes mellitus, malignant neoplasms, etc. are among the factors that initiate the manifestation of the disease. However, the studies devoted to evaluation of the endocrine glands in such patients remain unaddressed. Although it is known that, in particular, the thyroid gland takes an active part in the development of allergic dermatoses. Objective: To study the thyroid hormone balance in patients with chronic idiopathic urticaria.