To determine the effectiveness of the effect of dosed bicycle ergometric exercise on the cardiovascular system of persons with lower limb amputation to substantiate the adequate functional state of the motor regimen and appropriate methods and means of physical rehabilitation. Prospects for further research in this direction will be aimed at the wide implementation of the obtained results in the case of individual prescription of the movement regime, the formation of the volume and intensity of physical exertion, the selection of appropriate forms, methods, and means of physical rehabilitation of persons with different levels of loss (amputation) of the lower extremities.