The  problem  of  bone  trauma  and  restoration  of  bone  integrity  with defects of various localization, shape and size is particularly relevant today.    Objective:To  determine  the  features  of  post-traumatic  dynamics  of  the  mineral elements content in the bone tissue of the mandible using octacalciumphosphate.Materials and Methods: The study was conducted on 65 sexually mature male rabbits weighing  2.5-3.0  kg,  aged 6-7  months which  were  divided  into  3  groups  (20  rabbits each): Group I -control -the bone tissue defect healed under a blood clot; Group II -the defect was filled with native octacalciumphosphate (OCP-N); Group III -the defect was filled with octacalciumphosphate with chitosan and ampicillin (OCP-N-Chitosan-Ampicillin). Five intact animals were used to study the normal mineral composition of the rabbit mandibular bone tissue (MBT). The content of five mineral elements was determined using atomic absorption and emission spectral analysis. Data was carried out after 7, 14, 21, 28, 35, 56, and 84 days.

   Results:It was established that the calcium and phosphorus content in the MBTwere lower thanin the control, but higher than normal. Magnesium and sodium levels with OCP-N   were   similar   to controls,   while   with   OCP-N-Chitosan-Ampicillin,   they returned  to  normal.  Sodium  levels were higher  than  controls.  Sodium  levels  were higher than the first control group data. Magnesium levels, while using OCP-N were higher than the parameters for intact animals and first control group throughout the entire  experiment.  While  using  the  OCP-N-Chitosan-Ampicillin  material  they were higher than the first control group. The potassium content throughout the experiment in  both  experimental  groups  was  lower  than  data  of first  control  group.  However, when using OCP-N  material on day 84, the studied parameter remains significantly lower  than  in  intact  animals;  with OCP-N-Chitosan-Ampicillin  it  returns  to  normal values.

   Conclusions:The mineral composition of bone tissue undergoes significant changes following a bone-destructive injury, characterized by a substantial increase in calcium, phosphorus, and magnesium levels. The dynamics of sodium and potassium content are less pronounced. When the bone defect is filled with the osteoconductive material OCP-N-Chitosan-Ampicillin, the levels of calcium, phosphorus, magnesium, sodium, and potassium return to normal values by the 84th day after injury.

Keywords: rabbits, bone tissue, lower jaw, mineral elements, reparative osteogenesis, osteoplastic materials, octacalcium phosphate.