Background and objectives. Peritoneal relapse (PR) is the most common pattern of gastric cancer (GC) recurrence after radical treatment. Currently, a variety of adjuvant intraperitoneal chemotherapy methods are being tested for their efficacy in reducing the level of PR. 

Methods. The radical treatment results of 226 patients with localized and locally-advanced GC have been analyzed. To select a group of patients with indications for adjuvant intraperitoneal therapy, a study of independent predictive factors and the development of a predictive PR nomogram for gastric cancer was completed.

Results. As a result of the analysis of about three dozen potential factors in mono- and multivariate analysis, the impact on PR risk was confi rmed by 4 independent predictive factors, namely: serosal invasion and its size (HR 9.36, p <0.001), morphological type according to Lauren (HR 5.3, p <0.001), index of regional lymph node involvement (HR 2.23, p = 0.015) and localization of the tumor in the stomach (HR 3.98, p <0,001).

Conclusions. A predictive PR risk nomogram of gastric cancer after radical surgical treatment has been developed based on the identifi ed independent factors, and it is of great clinical importance as a tool for segregating patients who require adjuvant intraperitoneal chemotherapy.

The presence of several different autoantibodies (auto-AT) at the same time is a specific peculiarity of the “autoantibody profile” of SLE (systemic lupus erythematosus). It is known that the induction of auto-AT formation involves both nonspecific and antigen-specific immunoregulatory disorders. In apoptosis, the primary changes in the cell membrane composition or/and the excretion of intracellular compounds into the intercellular milieu lead to an inflammatory reaction. The purpose of the study was to highlight the connection between apoptosis and secondary necrosis of granulocytes and
mononuclear (lymphocytes and monocytes) with inflammation activity in patients with SLE to improve diagnosis and basic therapy efficacy. In patients with SLE, secondary necrosis of granulocytes was 3.4 times higher compared to healthy control. Moreover, the level of apoptotic monocytes was 1.87 times higher, and secondary necrosis of monocytes was 5.58 times higher than healthy control. The secondary necrosis of lymphocytes was higher by 9.0 times than in the case of healthy control. The usage of Apolect technology in patients with SLE allows differentiating various cell types of immunological inflammation with the analysis of the degree of apoptosis and secondary necrosis of immunocompetent cells (granulocytes, monocytes, lymphocytes) to determine the agg