Studying the history of the formation and development of the medical education system revealed the peculiarity of its indi-vidual stages, the specifics of the economic level of American society, political situation, social needs and culture of formation in a certain period. At each stage, the task of meeting the educational needs of American society was addressed. The article ana-lyzes the state of research of the investigated problem in domestic and foreign scientific sources. It is generalized that the main attention of scientists is focused on the general issues of formation of the medical education system: its beginning, moderni-zation and reform at different stages of development. The historical and pedagogical aspect of studying the system of doctors’ professional training is one of the most important in the research, as it provides an understanding of the achievements or draw-backs of the past. Modern higher medical education in the United States is a unique phenomenon, largely due to its historical development, full of social and economic challenges, and the ability of American government to respond quickly and effectively to the needs of the time. An important milestone in the development of American medical education was the creation of coor-dinating and monitoring organizations. The National Board of Education was established to coordinate the education system, and the American Medical Association and the Association of American Medical Colleges were established in medical educa-tion. This was the beginning of the introduction of educational standards provided in medical schools. Significant changes in the field of higher medical education in the United States started with the publication of a report by A. Flexner, who proposed to reduce the number of medical schools, complicate requirements for admission to medical schools, involve staff and students in research, strengthen state control in licensing medical schools. These Reformation processes became the point of gradual devel-opment of modern American medical education. In the twentieth century, the accumulation of knowledge and the development of medical science contributed to the differentiation of the medical profession in certain subsections