Під нашим спостереженням перебувало 67 хворих на хронічний генералізований пародонтит 1 і 2 ступеня важкості у фазі загострення без істотних супутніх захворювань. При встановленні клінічного діагнозу використовували загальноприйняті методи. Пацієнтів основної групи (36 осіб) лікували за допомогою запропонованого засобу, в контрольній групі (31 особа) – застосовували традиційну терапію. Для оцінки ефективності лікування визначали пародонтальний індекс (Russel, 1967), вимірювали глибину пародонтальних кишень, з метою об’єктивізації результатів впродовж усього спостереження контролювали гігієнічний стан ротової порожнини. Отримані нами клінічні дані оцінювали безпосередньо після лікування, а також через один і три місяці після нього.

Результати. Спостереження за пацієнтами основної групи засвідчило, що застосоване лікування спричинило швидку ліквідацію симптомів запалення вже після 1-2 сеансів терапії. Бажаний терапевтичний ефект від проведеного лікування в основній групі зафіксований в 78% випадків, у контрольній – у 51%.

Висновки. Запропоновані нами лікарські форми – гель та плівка на основі амізону є ефективними засобами для лікування пародонтитів, вони зручні у використанні, не викликають побічних ефектів і можуть бути рекомендовані для широкого клінічного застосування. Ключові слова: лікування пародонтиту, гель, плівка, амізон. 

The study aims to review the involvement of different dietary habits in Laotian, Cambodian, and Vietnamese populations in reducing COVID19 impact.
Materials and Methods. The methods of collection, systematization, analysis and generalization of information data have been used. The analysis of literature in scientific databases and analytical platforms by the listed keywords has been performed; all relevant references in the found sources have also been reviewed.
Results and Discussion. Coronavirus disease (COVID-19) outbreak is an ongoing pandemic caused by a highly pathogenic human coronavirus known as SARS-CoV2. Current epidemiology reported that more than 500 million cases of COVID-19 occurred in more than 180 countries worldwide. When the upper respiratory tract gets infected
by low pathogenetic HCoVs, it typically triggers a mild respiratory disease. In contrast, when the lower airways get infected by highly pathogenic HCoVs, such as SARSCoV2, acute respiratory distress syndrome (ARDS) may occur and even fatal pneumonia. Such a situation causes the need for an urgent search of effective treatment measures. A very low incidence of SARS-CoV-2 in Laos and Cambodia, as well as low mortality rate due to COVID-19 in Vietnam and Laos, are extremely interesting, especially because of their early exposure to the virus, continuing ties to China, relative poverty, and high population density. The use of several spices and aromatic herbs as natural treatments for several illnesses, including viral infections, has been reported since a long time ago. The research reviewed three integral elements of Laotian, Cambodian, and Vietnamese diets, such as special culinary spices and herbs, coconut oil, and palm oil-rich for saturated fatty acids as well as fermented shrimp paste. Environmental and population genetic
causes may be forwarded but moreover local dietary habits may have even a role in this evidence. Therefore, all these items highlight the possibility of a significant contribution of local cuisine and diet into the impact on  appropriate anti-inflammatory and immune-resistant mechanisms of the human population.
Conclusions. The review on Vietnam, Cambodia, and Laos inhabitants' diet helped to suggest the dietary factors having the contributing potential of reducing the severity of SARS-CoV-2 symptoms

Keywords: COVID-19, spices and herbs, Indo-Chinese cousin, ginger, black pepper, coconut oil, fermented shrimp paste

Biometric parameters of fruits and seeds of Paulownia tomentosa collected from trees growing in soil and climatic conditions of different geographical locations of Odesa, Zakarpattia (Mukachevo) and Lviv regions of Ukraine, as well as technical and absolute germination, germination energy, mean germination time and weight of 1000 seeds, were studied. The effect of different temperatures on seed germination in soil was evaluated under two temperature regimes. The influence of the duration of pre-soaking on seed germination was also determined. Pre-soaking
of seeds in water and solutions of five different stimulants on germination in soil was also investigated. It has been found that in the conditions of Odesa region, the species formed larger fruits and the seeds were characterized by significant rate and uniformity of germination. Lowering of germination temperature caused a decrease in germination energy, laboratory and absolute seed germination, and increased the mean germination time of seeds. Pre-soaking of seeds increased significantly germination rate and its duration was associated with the parameters: germination energy, technical and absolute germination. Among the three seed collections, the highest technical germination was recorded for seeds from Lviv region. The seeds from Odesa region had the highest germination energy. The seeds were characterized by high germination rate in soil regardless of the geographical location of seed collection under the conditions of Ukraine. The highest germination in soil was found for seeds, collected in Lviv. Temperature during germination significantly affected the germination of seeds in soil. Under the temperature regime of 21 to 25 °C, soil fertility parameters were significantly higher. Pre-soaking of seeds had the highest stimulating effect on further germination of seeds in soil among the studied treatments. Pre-treatment of seeds with germination stimulants had generally a positive effect, increasing germination in soil.
Key words: biometric parameters, germination, pre-soaking, stimulators, temperature regimes, weight of 1000 seeds

The forest raw material base of Ukraine needs a long-term recovery, caused by current shortage of wood and in the long-term perspective, as well. One of the ways to solve this problem is to create plantations of Paulownia tomentosa (Thunb.) Steud., which are able to accumulate in a very short time a significant stock of wood, suitable for industrial use. Determination of the physical and mechanical properties was carried out on samples of standard sizes. It has been established that the density of paulownia wood, grown under the conditions of the Western Forest Steppe of Ukraine, ranges from 329–342 kg·m-3 (sapwood, heartwood) to 416 kg·m-3 (middle part between the sapwood and heartwood). Under the conditions when only air moisture influences the wood, the moisture content increases up to 12.9 %. Static bending strength, compressive strength parallel to grain, static hardness, modulus of elasticity of sapwood and heartwood parts of the trunk are characterized by minimum values, and the middle part (between the sapwood and heartwood) – by maximum ones. Therefore, in terms of appearance and texture, the wood has the most similarity with the wood of common ash; considering its density value, paulownia wood resembles the wood of Norway spruce and silver fir, but due to lower moisture absorption and the content of tannins, it is more resistant to decay than the mentioned species; the middle part according to some mechanical indicators is close to common pine wood, therefore, it can be widely used in building industry. Paulownia tomentosa wood is advisable to be used as a promising material for the production of firewood and wood pellets. The data we have obtained can be taken into account by specialists in the woodworking, furniture and agricultural industries when planning the creation of plantations and the use of its wood.
Key words: modulus of elasticity, moisture content, plantations, porosity, shrinkage, strength,
swelling.

A new range of threats arose at the beginning of the 21st century, and the current global and national security systems could not respond effectively. Climate change threatens human health and well-being. Extreme weather events, food and water shortages, and the growth of infectious diseases increase the burden on healthcare systems. Progress in international health partnerships in 2022 has stalled and, in some cases, is reversing. The constant increase in the cost of medical services and medicines has a negative impact on the effectiveness of the functioning of national healthcare systems. Out-of-pocket healthcare costs cause financial hardship for more than 930 million people and push about 90 million into extreme poverty each year. If current trends continue, the World Health
Organization predicts that by 2030, up to 5 billion people will be unable to access or afford health services. For further advancement in global health security and to ensure better health for all in a changing world, reducing the cost and guaranteeing access for indigent patients to innovative medicines for treating a wide range of life-threatening diseases is essential. To minimize the cost and ensure access to medicines, it is proposed to create international research centers for developing innovative medicines without patent protection with centralized funding and appropriate planning for high-level interdisciplinary fundamental and applied research based on the needs of healthcare systems worldwide.
Keywords: Healthcare; cost of medicines; patent protection; research center