Introduction. In modern societal conditions, the pathology of the affective sphere occupies a special place among general medical problems. One of the central phenomena, both in depression and in another common affective disorder – mania, is the issue of self-esteem. Aim. To study the presence of depressive disorders depending on the presence of the inferiority phenomenon. Methods of research. The study uses data from the survey of 612 university students of higher education institutions of III and IV accreditation in Lviv, conducted in October – November 2021. Among the respondents, 57.35% (n=351) were men and 42.65% (n=261) were women. The average age of respondents was 20.31±2.99. Respondents filled out questionnaires of the Comparative Feeling of Inferiority Index (CFII) to determine the presence or absence of phenomenon of inferiority (PhI) and Beck’s Depression Inventory – to determine the level of depression. Results. Most often, depression was found in the group of individuals with the index of PhI superiority, who had signs of an extreme desire to compensate for an excessive feeling of inferiority in any way. In particular, about a third (32.35% [21.83–43.86]) of those surveyed had depression, while in the group with no altered self-esteem, the value was 21.36% [17.88–25.05] (p=0.042). The highest median value of scores on the depression scale was also found in the group of individuals with the index of PhI superiority (10 [6; 15] points), p<0.001, compared to respondents with no altered self-esteem. A comparison by gender showed a significantly higher number of women with depression than men; 46.67% [29.40-64.35] of women with the index of PhI superiority had symptoms of depression. Median values of depression scores were also higher in women in all studied subgroups (p<0.05). Conclusions. Research and understanding the phenomenon of inferiority is important for its in-depth study in the context of association with other psychopathological human conditions, especially in the current environment.
УДК 61(091.2):616.927:615.371/.372
Streszczenie. W artykule przedstawiono informacje o pracownikach laboratorium tyfusu plamistego, która została utworzona przez profesora Rudolfa Weigla na Wydziale Biologii Ogólnej Uniwersytetu Jana Kazimierza we Lwowie. W środowisku uniwersyteckim i akademickim nazywano ich “Weiglowcy”.
Анотація. В статті наведено інформацію про співробітників лабораторії висипного епідемічного тифу, яка була створена професором Рудольфом Вайглем на кафедрі загальної біології Львівського університету імені Яна Казимира. В університетській та академічній спільноті, їх називали «Вейгльовці».
The demand for dependable near-infrared (NIR) probes, capable of sustained fluorescence within living systems and facile conjugation with biomolecules like antibodies and proteins, has been significantly on the rise, attributed to the substantial rise in the use of NIR imaging techniques and devices, with extensive integration into clinical diagnostics. Antibody conjugates are vital for targeted and selective bioimaging, enabling precise visualization of specific biomolecules within complex biological systems. Their multiplexing capability allows simultaneous detection of multiple targets, while their dynamic imaging capability enables real-time monitoring of cellular processes. Clinically, antibody conjugates have significant applications in disease prognosis, diagnosis, and monitoring. In this work, we report the synthesis of a new symmetrical NIR squaraine dye (SQ-58) with multiple carboxy anchoring groups for ease of coupling with antibodies. The dye showed decreased absorption and fluorescence intensity in phosphate buffer (PB) due to enhanced dye-aggregate formation. However, in the presence of bovine serum albumin (BSA) in PB, SQ-58 showed an enhanced fluorescence signal along concentrations of BSA. SQ-58 showed no cytotoxicity when tested in white laboratory mice while providing strong fluorescence when injected in vivo. Conjugation of SQ-58 through the carboxylic groups to the isotypic mouse IgG antibodies (IgG-SQ-58) resulted in uniform distribution of the targeted molecule in the whole cardiovascular system. The NIR signal of IgG-SQ-58 was stable for at least 7 days allowing the possibility of long-term imaging. Conjugation of SQ-58 to antibodies raised against NK-Ly lymphoma tumor cells allowed efficient discrimination of tumor cells grown in the abdomen of laboratory mice. Thus, to the best of our knowledge, we report for the first time a biocompatible NIR dye, SQ-58, that can be easily conjugatable to biomolecules, and its antibody conjugates for a wide range of bioimaging applications.
The article is dedicated to the life and professional journey of Oleksandr Filts–a renowned Ukrainian psychiatrist, psychotherapist, and scholar. It outlines the key milestones of his career and his contributions to the development of psychiatry, psychotherapy, and organizational work in Ukraine and Europe. Particular attention is paid to Oleksandr Filt's innovative concepts, academic achievements, and authority among the Ukrainian and international psychotherapeutic community.
УДК: 616-091(092)(477)
29 березня 2020 року минуло 80 років від дня народження Заслуженого діяча науки і техніки України, професора кафедри патологічної анатомії Донецького національного медичного університету Валерія Геннадійовича Шлопова – видатного українського вченого, талановитого педагога та організатора науки, одного з кращих представників української медичної інтелігенції. Є люди, яких уважають зразком і гордістю колективу, університету, країни, і скільки б часу не минуло, а пам'ять про них житиме в серцях людей, як і пам'ять про Валерія Геннадійовича Шлопова.