Psoriasis is related to the systemic diseases characterised by a complex of mutually conditioned pathogenetic links (immune, neuro-endocrine, infectious, etc.). Microbiocenosis of both healthy and pathologically altered skin can serve thepoint to assess the health of macroorganism. In chronic dermatoses a qualitative and quantitative change in skin microbial associations is observed. Changes in macroorganismare reflected in disorders of microbial landscape of all skin topographic zones. It should be noted, that the study of microbial skin flora in psoriatic patients is episodic and unstructured. Despite loads of suggested methods and therapeutic means used to treat psoriatic patients, their efficacy remains not high due to the uncertainty of aetiology, disease pathogenesis multi-factority and polymorphism of clinical manifestations. The purpose of our study was to study changes in microbial flora of psoriatic patients skin under NBUVB application

The effect of changes in cytokine profile is admitted to be an integral pathogenic mechanism of psoriasis. In this case, we believe that it makes sense to study the levels IL-4, IL-10, IL-8 and TNFα. The first two have an anti-inflammatory effect. IL-4 suppresses cytokine synthesis and shows an apparent antiproliferative potential. IL-10 also does some inhibitory activity towards cytokines, but at the same time it is an immunosuppressive agent. IL-8 belongs to the main chemokines. TNFα is a part of a group of anti-inflammatory cytokines and shows cytolitic and antineoplastic effects. Endocrine disorders hold the leading position in pathogenesis of psoriasis. In particular, there has been observed lately an increase in the level of thyreopaties, which is considered to beconnected with environmental deterioration. Thyroiddisorders, associated with both its suppression and functional improvement are characterized with the appearance of autoimmune reactions, and circulatory antibodies to thyroglobulin (Tg). In this aspect, we consider it to be prospective, to examine the antibodies to thyroidperoxidase (TPO) and Tg in the patients with psoriasis.

Changes in the macroorganism state are reflected in the disorders of microbial landscape of all topographical skin zones. It should be noted that the study of the skin microbial landscape in patients with psoriasis have episodic and unstructured nature. Thus, it is claimed that the findings of the skin microbiocoenosis disorder in patients with psoriasis are characterized by changes in the quantitative and qualitative spectrum of microorganisms. purpose of our work was to investigate the quantitative composition of microscopic flora and the degree of skin induration of patients with psoriasis, depending on the clinical course (clinical form, stage) and duration of the disease

One of the important problems in modern dermatology is to improve treatment efficiency of acne being a common cause for cicatricial skin changes, loss of performance capability and social activity and negatively affects the psycho-emotional state of patients and their quality of life. The topicality of the disease is due to the high degree of its proliferation, chronic and recurrent course, and resistance to existing therapies.
Objective: to study the effect of low level laser radiation (LLLR) on pustular microflora in acne patients and to determine the reasonability of its application in the course of complex treatment of such patients.

A high incidence of acne, tendency to a chronic course with the formation of resistance to treatment and frequent development of deep forms determine the important medical and social significance of the problem. Acne is one of the most important problems in modern dermatology, being a common cause for cicatricial skin changes, loss of performance capability and social activity and negatively affects in the psycho-emotional state of patients. The topicality of the disease is due to the high degree of its proliferation, chronic and recurrent course, and resistance to existing therapies. The development of acne is due to the combined effect of endogenous and exogenous factors, including the important role played by the changes of immunological reactivity, justifying the administration of immunotropic techniques and drugs in their comprehensive treatment. Reducing the effectiveness of skin diseases treatment, including that of acne, at present, is associated with developing resistance to drugs, which causes the use of non-drug methods in dermatology nowadays., including low-intensity (with capacity of 1-20 mV) laser therapy, which possesses an anti-inflammatory, antibacterial or bacteriostatic action, stimulates the immune system factors , without causing any side effects or complications.
Objective. Тo increase the effectiveness of treatment of аcne during complex treatment that included combined laser therapy with consideration for indicators of systemic immunity.