Introduction. Liver diseases and pathology of the organs of mouth cavity are interconnected. Smoking, usually increases the manifestations of the underlying disease and affects the course. The aim. To investigate the effect of chronic toxic hepatitis of nicotine-dependent patients and of patients without a bad habit on their periodontal status.

Materials and methods. During the clinical examination of the oral cavity of 86 patients, the depth and incidence of inflammation of the gum were determined using the number of the Svrakov's number (SN); the conditions of hygiene of the oral cavity were estimated using the Silness-Loe (S-l) index; Periodontal Index (PMA) and Bleeding Index (PBI). General histomorphology was studied on drugs stained with hematoxilin-eosin and by the method of Gerlich and van Gieson.

Results. It is established that the indicator of SN had the highest value among patients of group II (2,15±0,13), it was probably (p < 0.05) higher relatively to the group I and comparison group. In the smoking patients with chronic toxic hepatitis, in spinous layer of epithelium was determinanted karyorhexis, karyolysis with the formation of cell debris; basal layer cell proliferation, acanthosis, angiogenesis. We detected damage to collagen and elastic fibers of the periodontal, wich correlated with the intensity and duration of the bad habit. In areas of pronounced alterative changes colonies of bacteria were discovered.

Conclusions. Thus, the results obtained in nicotine-dependent patients with chronic toxic hepatitis visualize damaging effect on the epithelium and weakening of the histohematic barrier of the oral cavity and promotes the reproduction and penetrationof pathogenic microflora into the underlying tissues.

Keywords: periodontium, chronic toxic hepatitis, nicotine-dependent. 

We observed a case of COVID-19 reinfection.

Нами спостерігався випадок повторного захворювання на COVID-19.

The hair texture changes and hair loss are often the first symptoms of diseases of internal organs. The aim - to study the changes in hair structure, which are reflected in the quality and appearance of hair, to monitor structural changes in the hair and to evaluate the impact of diseases of internal organs in patients in order to improve therapy.Over the course of one year, 40 patients were examined who complained of excessive hair loss and 25 persons, which constituted a control group of apparently healthy people. To determine the structural changes in the root and shaft of the hair, macro- and microscopic examination was used, which was carried out on MBI-3 microscope with an AU-12 binocular attachment (600x magnification). During the examination, the root and the surface of the shaft were carefully examined for cracks or other damage. The pyruvate and pyruvate dehydrogenase tests and antithyroid antibody titer tests were used to detect latent diabetes and autoimmune thyroiditis.
Conclusion: The effect of using lotion and shampoo with dimethylsilanediol in comprehensive treatment was obtained starting from the second month of therapy, which was confirmed by microscopic examination of the hair: hair roots were covered with sheaths, a tile pattern was observed along the entire length of the hair shaft, there were no ridges or grooves. A complete structural restoration of the hair was observed in 70% of patients.

Introduction & Objectives: The COVID-19 pandemic has made adjustments both in the general life of people and in the medical practice of doctors of many specialties. In addition, doctors - dermatovenerologists at daily appointments increasingly consult users with drug-induced rashes that occurred after treatment of COVID-19. Medicinal lesions of the skin with a viral coronavirus infection are necessarily associated with a large number of drugs of various pharmacological groups prescribed to the patient, which, interacting, can have a toxic effect on human protection. One of the most important manifestations of the toxic effect of drugs on the human body is toxic epidermal necrolysis (TEN).
Purpose The research method was to analyze the anamnestic data from TEN and characterize the amino acid composition of the blood serum of such patients with damage to more than 50% of the skin area.
Materials & Methods: 6 used TENs were under our observation, during periods of various diseases (initial, acute) that had undergone COVID-19, the area of the affected skin was determined by the rule of “nines”, the amino acid composition of blood serum was determined by the method of thin-layer two-dimensional chromatography.

In order to determine the indicators of carbohydrate metabolism and their influence on the course of superficial candidiasis, 97 patients with different severity of this disease were examined.The study of carbohydrate metabolism included the determination of fasting blood sugar level to detect the overt diabetes and glucose tolerance test (with the load of 75 g of glucose).The impaired glucose tolerance was detectedin 36 patients, so their levels of
glycosylated hemoglobin and fructosamine wereadditionallydetermined.HbA1c level was determined in whole blood by ion exchange chromatography. Fructosamine was measured by kinetic colorimetric method in both serum and plasma.Blood sampling was performed on an empty stomach from the cubital vein. The studies were carried out immediately after sampling.The Sentinel CH test system from Intero (Italy) and a spectrophotometer with a 405-425 nm filterwere used for the research.
Results: The research showed that in the group of patients with candidal lesions, there is a direct dependence of HbA1c and fructosamine on the severity of the disease.In patients with minimal and moderate candidal lesions, an increase in HbA1c and fructosamine indicators was observed compared to similar indicators in the control group by 1.54 and 1.21 times respectively. In patients with significant candidal lesions and relapses, the concentration of HbA1cincreased by 2.59 timesand of fructosamineby 2.26 times in relation to the indicators of the control group.