Background: Prophylaxis with von Willebrand factor is recommended in people with severe von Willebrand disease (VWD), regardless of age. WIL-31, the only prospective study with an on-demand run-in study as an intraindividual comparator, demonstrated the efficacy and safety of prophylaxis with the plasma-derived von Willebrand factor/
factor VIII concentrate wilate (Octapharma) in adults and children with VWD of all types. Prophylaxis is often considered in young children and adolescents with severe VWD and recurrent bleeding, although limited data support this strategy

Abstract

Attitudes toward people with disabilities reflect the level of moral and cultural development of societies, their cohesion, and their ability to coexist harmoniously. Studying students’ attitudes toward wheelchair users in the context of the armed conflict in Ukraine is an important step in exploring the sociodemographic determinants of those attitudes and the evolution of social awareness among young people. The research was conducted twice, in 2022 and 2024, covering 1,453 and 986 Ukrainian students, respectively, from medical, humanities, and social science programmes at universities in Kyiv, Ternopil, Ivano-Frankivsk, and Lviv. The method used was a diagnostic survey with a standardised questionnaire, the Multidimensional Attitudes Scale Toward Persons With Disabilities (MAS-UA). Results are presented in subscales, with higher values indicating more negative attitudes toward individuals with disabilities. The results indicate significant differences in the first subscale of the MAS (39.94 ± 5.97 in 2022 vs. 33.76 ± 10.07 in 2024), suggesting an increase in positive emotional-evaluative attitudes in the later study. The overall assessment of social attitudes has also improved (79.22 ± 11.98 vs. 74.02 ± 18.31). The cognitive and behavioural aspects of attitudes are more stable and change relatively slowly. The armed conflict has triggered the mobilisation of the Ukrainian youth to increase efforts for the benefit of people with physical disabilities. The sociodemographic ‘profile’ plays a role in shaping emotional attitudes and the overall MAS score. Older students, women, those living in large cities, married individuals, students in medical fields, and those who identify with a religion exhibit a more positive attitude. The increase in positive emotions, reduction in tension, stress, helplessness, and shame indicate an improvement in mental well-being. However, a decline has been noted in feelings of relaxation, calmness, and composure. A daily visual or direct contact with people with physical disabilities has significantly improved affective attitudes, highlighting the importance of direct interactions in fostering empathy and understanding.