УДК: 616.24-006-089-06[.001.36

The aim of the study was to identify factors that are associated with complications after surgery for lung cancer.

Materials and Methods. Retrospective analysis of the surgical treatment results in patients with lung cancer who were operated on in 2010-2014 at the department of thoracic surgery of the Lviv Oncological Regional Treatment and Diagnostic Center. The study included 461 patients. The data of each patient were divided into the following groups: general characteristics, tumor characteristics, treatment characteristics, and complications. The whole cohort of patients was analyzed and their separate subgroups were compared by age, type of complications, and type of surgery.

Results and Discussion. Elderly patients have three times higher levels of postoperative dyspnea and much higher levels of cardiac arrhythmias. Pulmonary complications are more common in men, after more aggressive surgeries with longer time of operative pulmonary ventilation; increase with age. This subgroup is also characterized by longer postoperative period and a higher in-hospital mortality rate. Postoperative complications such as dyspnea, fistula of the bronchial stump, and pleural empyema, higher levels of pleural punctures, and postoperative bed-day were more common in the group of patients who underwent pneumonectomy. A higher level of postoperative pneumonia and a longer drainage period were observed in the group of other operations. It is noteworthy that the level of dyspnea in elderly patients who underwent pneumonectomy is three times higher.

Conclusions. There are age-related features connected to the onset of postoperative complications in patients with lung tumors who have undergone surgery. Complications typical for the patients after different types of operations were found. It is established that the age of patients and the type of surgical treatment significantly change the palette of postoperative complications. An improved method for predicting complications is required.

УДК: 614.1:313.13:312.2:616.22-006.6(477)(477.83)"2010/2019"

SARS-CoV-2 infection, in the vast majority, affects adult patients. The severity of COVID-19 and mortality are directly correlated with the increasing age of patients and the number of comorbidities. However, with the further development of the COVID-19 pandemic, severe cases of COVID-19 have been reported in children. About 0.8-1% of sick children require hospitalization in an intensive care unit. The main syndromes that cause disease severity and mortality in children are acute respiratory distress syndrome, multisystem inflammation syndrome and multiple organ failure. The rapid development of severe respiratory failure and hypoxemia in respiratory distress syndrome leads to the use of various methods of respiratory therapy, and in case of their ineffectiveness to extracorporeal membrane oxygenation (ECMO). In our report, we present two clinical cases of successful use of ECMO in children with COVID-19, who developed severe ARDS.

The measles epidemic was observed in Ukraine during 20172019. According to WHO, in Ukraine there was registered the highest number of measles cases in Europe during that period [8]. Measles is characterized by an acute course with fever, maculopapular rash, cough, conjunctivitis and can lead to central nervous system complications (encephalitis, encephalomyelitis) and bronchopulmonary system complications (laryngotracheobronchitis, bronchiolitis, pneumonia). In immunocompetent patients, viremia ends after the end of clinical signs, in contrast to immunosuppressed individuals, who could develop viremia from one month up to a year. We have described a case of measles inclusion body encephalitis (MIBE) or subacute measles encephalitis (SME) in an unvaccinated child with an acute lymphoblastic leukemia (ALL). The diagnosis was confirmed by the synthesis of IgG antibodies to the measles virus in the cerebrospinal fluid and by the MRI results. The disease had a dramatic course and ended in death.

The purpose of this chapter is to highlight the opportunities for digitizing important processes in the healthcare system to improve the efficiency of population health management. The introduction of these digital processes will increase patient satisfaction with the healthcare system, as well as provide a holistic outlook of patient health through access to data and give patients more control over their own health. Healthcare managers will also be using the developed internet applications to conduct clinical audits and monitor health problems in the administrative district. It is proposed to develop and use free internet applications and computer programs, namely 1) drug compatibility test online application, which is designed primarily for students; 2) electronic individual antenatal drug passport for a promising way to predict, prevent, and reduce the risk of allergic reactions; and 3) medical intelligence app using the artificial intelligence technologies to develop an individual educational trajectory for doctors and pharmacists.