Type 2 diabetes (T2D) and hypertension are common health conditions that often occur together, suggesting shared biological mechanisms. To explore this relationship, we analysed large-scale multiomic data to uncover genetic factors underlying T2D and blood pressure (BP) comorbidity. We curated 1,304 independent single-nucleotide variants (SNVs) associated with T2D/BP, grouping them into five clusters related to metabolic syndrome, inverse T2D-BP risk, impaired pancreatic beta-cell function, higher adiposity, and vascular dysfunction . Colocalisation with tissue-specific gene expression highlighted significant enrichment in pathways related to thyroid function and fetal development. Partitioned polygenic scores (PGS) derived from these clusters improved risk prediction for T2D-hypertension comorbidity, identifying individuals with more than twice usual susceptibility. These results reveal complex genetic basis of shared T2D and BP mechanistic heterogeneity, enhancing comorbidity risk prediction. Partitioned PGSs offer promising approach for early risk stratification, personalised prevention, and improved management of these interconnected conditions, supporting precision medicine and public health initiatives.
Background: In recent years, dramatic political changes and the ensuing war in Ukraine have led to a
signifcant increase in the number of stress-related disorders, in particular among military personnel.
The study was designed to evaluate the prevalence and distribution of mental health disorders among
the Ukrainian military referred to inpatient assessment and treatment at a large military psychiatric
hospital located in Kyiv, Ukraine.
Methods: The study was a retrospective analysis of 9109 inpatient admissions to the psychiatric clinic
of national military medical clinical centre in Kyiv, Ukraine, between January 2014 and December
2018. Most of the patients were contracted military service ofcers, 2014-2018.
Results: The population sufered from a wide range of mental illnesses. Neurotic, stress-related, and
somatoform disorders were predominant among the ofcers, while psychotic disorders, personality
disorders, and mental retardation were prevalent among the conscripts. In 2016-2018, the nosological
structure of mental disorders remained stable with the highest prevalence of stress-related and
somatoform disorders, except a decrease in substance use disorders and an increase in psychotic
disorders. Among the outpatients discharged (n=128) in 2017-2018, the majority had sleep disturbances
and fashbacks (73%); anxiety and irritability (84%); and sufered from fatigue and low mood (80.9%).
The level of satisfaction with the social benefts and support from the authorities of the veterans was
extremely low (7.4%).
Conclusion: The study revealed the impact of war trauma on the mental health of the service
members, necessitating the development of specifc preventive measures and digital mental health
tools to support military personnel resource shortages and stigma.
Human autonomy in the field of healthcare as one of the fundamental principles in medical practice, the value of legal medicine and a tool for the formation of a human-centered healthcare system has been researched. Medical sorting and autonomy in decision-making have been considered, clinical and priority triage has been allocated, key principles of priority sorting have been proposed. It has been found out that the principle of autonomy in priority medical sorting is subject to significant restrictions, which negatively affect the observance of human rights in the field of healthcare. It has been noted that ensuring the individual mobility of persons with disabilities with the maximum possible degree of their autonomy, independence from outside assistance will guarantee the constitutional principle of equality of all people in their rights and freedoms.
The spectrum of definitions of the notion “medical tourism” has been outlined based on the results of the original review, and the authors’ vision of the said definition has been proposed. The WMA Statement on Medical Tourism has been analyzed and general principles for the functioning of medical tourism have been identified. The basic provisions for patients receiving services in the field of medical tourism and physicians involved therein have been crystallized on the basis of the said Statement. The experience of foreign countries in which the outlined sphere of tourism is actively developing, and which have the recognition of quality by WHO, has been covered. Authors’ axioms for the development of medical tourism, which can be useful for any country that is willing to build legal medical tourism, have been proposed.
The recent experience of using social media by the Ukrainian scientific and medical journal "Proceedings of the Shevchenko Scientific Society. Medical Sciences" DOI: 10.25040/ntsh (Medical Sciences) is presented, which have become important tools for increasing the visibility of medical journals. Social media have become an important tool for enhancing the visibility of medical journals. Social media facilitate the dissemination of knowledge, promote publications, engage audiences, and support the development of professional communities. Platforms such as LinkedIn, Facebook, and X (formerly Twitter) enable the formation of networks among authors, reviewers, and readers, help disseminate content, and contribute to establishing a positive image of the journal. Graphic abstracts are a promising tool for visual communication; however, they require standardized styles and the availability of consistent templates. A successful social media presence requires clear branding, high-quality content, bilingual communication, and a strategic approach. Although social media activity does not automatically lead to increased citation rates, it contributes to author promotion and the expansion of the journal’s reach. The mission of the "Medical Sciences" journal is to establish a global scholarly presence, foster open communication, and support Ukraine especially during wartime through scientific dialogue.
Keywords: medical science, medical journals, visual abstract, scientific writing, social media, communication, scientific publishing, journal club.