Dystrophic changes of all periodontal structures and teeth in patients with periodontitis and generalized periodontitis were investigated in the study. Characteristic signs of the gums’ pathological contour, as well as other clinical and radiological features of dystrophy differ in patients with periodontitis and generalized periodontitis and contribute to the improvement of their differential diagnosis. Ultrastructural examination of the patients’ gums with periodontitis revealed disseminated microthrombosis, mucoid edema and fibrinoid transformation of intermediate connective tissue, and coagulation-dystrophic changes in periodontal tissues and cells.
Key words: periodontitis, parodontosis, gingival ultrastructure, coagulation dystrophy

Primary splenic cysts (SC) are rare in children and are registered with a frequency of 0.07% to 1.0% of all surgical diseases of the abdominal cavity [2, 7, 13]. Beginning in 1929, when the disease was first reported, the classification of SC changed. SC were classified based on the presence or absence of epithelial membrane, pathogenesis, etc. SC are divided into true cysts, which have an epithelial membrane (SC type 1), and false cysts (SC type 2), in which the epithelial lining is absent. A separate group consisted of pseudocysts. They are usually of post-traumatic origin and are formed in the parenchyma of the spleen or subcapsularly as a result of hematoma transformation, less often – due to an abscess or infarction of the spleen [9, 11]. Depending on the presence or absence of the pathogen, SC are divided into parasitic and non-parasitic [1, 4, 5]. Parasitic SC are usually observed in endemic areas and are caused mainly by Echinococcus granulosus[1, 6, 10]. Modern classification is based on the pathogenesis of cysts and divides non-parasitic SC into congenital, neoplastic, posttraumatic and degenerative [3]. Primary SC account for 10% of all non-parasitic SC and are observed in different pediatric age groups. Most SC are asymptomatic, so they are mostly detected by accident during examinations (ultrasound, CT or MRI). In addition, they can be detected due to complications: suppuration or splenic rupture with bleeding, which requires urgent surgery [10, 12].

Aim: To determine the role of damage to the ultrastructural elements of the periodontal nervous system in the pathogenesis of dystrophic periodontal disease.
Materials and Methods: The basis of the experimental part of the study was the preparation of ultrathin sections from blocks of gum tissue of white rats, which were prepared using the UMTP-3M device. The study and analysis of biopsy samples was carried out with the help of an electron microscope UEMV-100K.
Results: With the help of transmission electron microscopy, it was found that from the rst minutes after the injection of hemolysate of isogenic erythrocytes into the rats, aggregates of erythrocytes, clumps of blood plasma, clusters of brin monomer masses, bundles of brin bers, platelet and homogeneous were present in the connective tissue of the gums, and in particular in the lumens of hemocapillaries microthrombi, which conrms damage to the ultrastructures of the periodontium, which lead to the development of a pathological process, which is described when simple coagulation dystrophy is reproduced.
Conclusions: Coagulative damage to the ultrastructural elements of the periodontal nervous system is one of the important factors in the pathogenesis of dystrophic periodontal damage. Under these conditions, trophic disturbances occur, similar to those that occur when the integrity of the nerve is disturbed – neurotrophic mechanism of dystrophy.
KEY WORDS: Сoagulation dystrophies, generalized decompensated thrombinogenesis, periodontium, nerves of the gingival mucosa membranes

Актуальність. Первинна дисменорея (ПД) — один з найпоширеніших видів гінекологічної патології, що спостерігається у 31–52 % молодих жінок, серед яких у 10 % інтенсивність процесу призводить до інвалідності. Патогенез ПД враховує вплив представника ейкозаноїдів тромбоксану А2 з вираженою судинозвужувальною дією. У статті надані результати клініко-гормонального обстеження жінок з ПД та розроблена на цій основі методика лікування. Мета: розробити й оцінити ефективність лікування ПД з урахуванням багатокомпонентного патогенезу захворювання. Матеріали та методи. Під спостереженням перебувало 60 жінок, випадковим чином розподілених на дві групи: 30 жінок із ПД (основна група) та 30 здорових жінок (контрольна група). Діагноз ПД встановлювався на підставі скарг пацієнток на болючі менструації та супутні симптоми, за винятком органічної гінекологічної патології та захворювань внутрішніх органів, на консультаціях у гінеколога й ендокринолога. Лікування хворих на ПД проводили комбінованим препаратом, до складу якого входять стандартизований екстракт Vitex agnus castus L., індол-3-карбінол, 3,3-диіндоліл-метан, екстракт пасифлори, екстракт каліфорнійської ешольції. Результати. В результаті лікування у хворих на ПД значно зменшилася інтенсивність болю, а у 60 % біль зник повністю, у всіх зник страх очікування наступної менструації, значно зменшилися прояви вегетативно-судинної системи (з 17 до 3 % пацієнток), вегетативні (від 10 до 0 % хворих), метаболічні й ендокринні (від 13 до 0 % хворих) розлади та розлади емоційно-психічної сфери (від 23 до 7 % хворих). Через 1 місяць після лікування поліпшення якості життя відзначали 70 % (21/30) пацієнток з ПД, а підвищення працездатності — 60 % (18/30), через 2 місяці — 93 % (28/30) і 83 % (25/30) відповідно. В жодної пацієнтки під час лікування не було виявлено побічних ефектів. Висновки. З огля­ду на безпеку та високу терапевтичну ефективність препарат на основі екстракту Vitex agnus castus можна рекомендувати для лікування молодих хворих із ПД тривалістю не менше трьох місяців.

Abstract.  Background. Primary dysmenorrhea (PD) is one of the most common types of gynecological pathology and is observed in 31–52 % of young women, in 10 % of them the pain is so intense that leads to disability. In the pathogenesis of PD consider a representative of eicosanoids — thromboxane A2 with a pronounced vasoconstrictor effect. The article presents the results of clinical and hormonal examination of women with PD and developed on this basis a method of treatment. The purpose was to develop and evaluate the effectiveness of treatment of PD, taking into account the multicomponent pathogenesis of the disease. Materials and methods. There were 60 women observation, randomly divided into two groups: 30 women with PD (main group) and 30 healthy women (control group). PD was diagnosed on the basis of patients’ complaints of painful menstruation and related symptoms, excluding organic gynecological pathology and diseases of the internal organs in consultation with a physician and endocrinologist. Treatment of patients with PD was performed with a combined drug, which includes a standardized extract of Vitex agnus castus L., indole-3-carbinol, 3,3-diindolyl-methane, passionflower extract, California escholzia extract. Results. As a result of treatment in patients with PD significantly reduced the intensity of pain, and 60 % completely disappeared pain, all disappeared fear of waiting for the next menstruation, significantly reduced the manifestations of autonomic vascular (from 17 % of patients to 3 %), autonomic (from 10 % of patients to 0 %), metabolic and endocrine (from 13 % of patients to 0 %) disorders and disorders of the emotional and mental sphere (from 23 % of patients to 7 %), no patient had a combination of symptoms.
Conclusions. Given the safety, high therapeutic efficacy, the drug based on Vitex agnus castus extract can be recommended for the treatment of young patients with PD lasting at least 3 months.
Keywords:  menstrual pain; hormonal balance; primary dysmenorrhea

Keywords: childbirth; fibrinolysis system; thrombocytopathy; thromboelastography; tranexamic acid; idiopathic arterial hypotension.