616-006.48-036

Symptoma琀椀c neuromas and cys琀椀c neck forma琀椀ons are clinically signi昀椀cant en琀椀琀椀es that require detailed diagnos琀椀c and therapeu琀椀c strategies. Trauma琀椀c neuromas resul琀椀ng from aberrant nerve repair, neurinomas of other orunknown origin, and cys琀椀c lesions of the neck with either benign or malignant e琀椀ology represent ongoing challenges in both di昀昀eren琀椀a琀椀on and treatment. This study presents a clinical case of neurinoma with secondary changes localized in the cervical region of a 44-year-old pa琀椀ent. Based on physical examina琀椀on, medical history, ultrasound,
and computed tomography, a diagnosis of lateral neck cyst was established. Following surgical excision of the mass, histological examina琀椀on con昀椀rmed the diagnosis: neurinoma with secondary changes.This case highlights the importance of mul琀椀modal imaging, minimally invasive procedures, and personalized surgical approaches. Emerging innova琀椀ons in the 昀椀elds of nerve regenera琀椀on and molecular diagnos琀椀cs hold promise for further advancing future paradigms of diagnosis and treatment. Given the polymorphic nature of lesions that may be localized in the neck region, their di昀昀eren琀椀al diagnosis o昀琀en presents challenges. Therefore, the selec琀椀on of appropriate treatment methods for neurinomas and cys琀椀c
neck forma琀椀ons requires an individualized approach, applica琀椀on of advanced imaging techniques, interdisciplinary
collabora琀椀on, and the use of methods with varying degrees of invasiveness

UDC 61:378:061.22-057.87

This study explores additional opportunities for the formation and improvement of hard skills and soft skills in medical students through their participation in student scientific societies. Given that the specifics of a doctor's work involve performing a range of diagnostic and therapeutic procedures while also requiring communication with patients and medical colleagues to make optimal decisions, the skill set used by physicians in their professional duties can be divided into hard skills—specialized (theoretical and practical) competencies—and soft skills, which include social and communicative abilities.
Today, higher medical educational institutions prioritize the development of strong professional knowledge and skills among their graduates but often do not place enough emphasis on the formation of flexible socio-communicative competencies. Therefore, extracurricular engagement in student scientific societies during university studiesserves as a universal opportunity for improving hard skills and developing soft skills such as communication, creativity,
teamwork, the ability to formulate hypotheses and draw conclusions, active listening, scientific discussion, quick decision-making, risk assessment, and prevention strategies.
The development of hard skills and soft skills is an essential component of the educational process in higher medical institutions. Exploring the opportunities and conditions for developing these skills among medical students, while integrating a broad range of methods into their training, will significantly enhance the competitiveness of future medical professionals and ensure their successful self-realization.

Objective: A convenient and effective method for the obtaining of a 4-thiazolidinone ring is theт[2+3]-cyclocondensation reaction of S,N-binucleophiles with different equivalents of the dielectrophilic synthon [C2]2+. For this purpose, we achieved the synthesis of intermediate N1- methylidenethiosemicarbazones 3a-b starting from 2-amino/allylsulfanyl-5-ethyl-1,3,4- thiadiazoles 1-b via Vilsmeier-Haak formylation reaction following by condensation with thiosemicarbazide in acetic acid medium.
Methods: Organic Synthesis, NMR Spectroscopy, Elemental analysis, Pharmacological screening.
Results: The interaction of intermediate N1-methylidenethiosemicarbazones 3a-b with αhalocarboxylic (monochloroacetic, 2-bromopropionic, 2-bromobutanoic) acids or α-bromo-γbutyrolactone in acetic acid at the presence of sodium acetate was performed. As results, a series of targeted 2-hydrazino-4-thiazolidinones containing 6-phenylimidazo[2,1-b] [1,3,4] thiadiazole moiety 4a-b and their 5-alkyl substituted derivatives 5a-d and 6a-b were obtained. The structure of the synthesized compounds was confirmed by elemental analysis and NMR spectroscopy. The synthesized compounds 3a-b, 4a-b, 5a-d, and 6a-b were evaluated for their in vitro antitrypanosomal activity against Trypanosoma brucei gambiense (Feo strain).
Conclusion: The results of in vitro screening of antitrypanosomal activity against Trypanosoma brucei gambiense (TBG) allowed us to identify three highly active compounds 4b, 5b and 5c, whichбexhibited significant trypanocidal activity with a range of IC50 values of 3.7-4.4 µM and were comparable to the reference drug nifurtimox (IC50 = 4.4 µM). 

In the present work, we report an efficient synthesis and antioxidant activity evaluation of some 4-arylimino-thiazolidin-2-ones. The structures of target substances were confirmed through 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The antioxidant activity of the synthesized compounds was measured in vitro by the method of scavenging effect on 2,2- diphenyl-1-picrylhydrazyl (DPPH) radicals. Notably, antioxidant activity was identified for the first time among 4-arylimino-thiazolidin-2-ones.

4-Amino-5-substituted-4H-1,2,4-triazole-3-thiols are versatile synthons for constructing of various biologically active heterocycles. This is provided by the close proximity of the amino and mercapto groups, which serve as readily accessible nucleophilic centers for the preparation of N-bridged heterosystems. One of the possible and convenient directions of using 4-amino-4H-1,2,4-triazole-3-thiols in heterocyclic synthesis based on their utilization in reaction with various carboxylic acids in the presence of dehydrating reagents, most often phosphorus oxochloride. Synthesized as follows [1,2,4]triazolo[3,4-b][3,4-b]thiadiazole derivatives may differ by various substituents in positions 3 and 6 such as alkyl-, aryl-, aryl(oxy)alkyl-, heteryl- etc. In this review, we presented the synthetic strategies and subsequent chemical transformations of the resulting triazolo[3,4-b]thiadiazoles, providing certain important class of functionalized compounds.