The research found a rapid increase in the level of immunoglobulin M, starting from the 3 rd day of the experiment in comparison with the control values, which clearly indicates its activation in particular, and stimulation of humoral immunity in general. In the later stages (on the 5 th and 15 th days) of the formation of experimental periodontitis (EP) and immobilization stress (IS), an increase of this indicator by 93.5% and 94.2% was found, respectively, against group I guinea pigs (p≤0, 05).
Regarding the content of immunoglobulin G in the blood, the highest growth rates were recorded in the fourth group of guinea pigs with EP and IS (on the 15 th day), which indicates a direct dependence of the duration of damaging factors on the level of these indicators and the body's ability to the protective response.
The results of the treatment showed the effect and the reduction of the activity of the studied classes of immunoglobulins. Thus, the use of thiocetam led to a significant decrease in 209 the content of Ig M and G in the blood, respectively, by 33.8% (p1≤0.05) and 41.7% (p1≤0.05) in EP and IS compared with the group of animals were not exposed to this drug, which indicates the immunocorrective effect of this drug on the studied tests.
After three years of the outbreak of Coronavirus Disease 2019 (COVID-19) pandemic, main tasks as to treatment and vaccination are still pending their solution. Today, it is known that SARS-CoV 2 coronaviruses are intracellular viral infections having an inevitable negative impact on all cells of the human body, including the blood cells. It is established that COVID-19 patients can be classified into mild, moderate, and severe. Modern literature does not describe ultrastructural changes of circulatory blood cells in patients with moderate course of this disease.
The dynamic development of endovascular interventional cardiac procedures contributes to the study of the cardiovascular system in vivo. The intravital evaluation of the coronary bed of the heart can be conducted with the help of intravascular ultrasound, the advantage of which for morphologists is the ability to assess the anatomy and geometry of the coronary arteries from the lumenal surface of the vessel.
UDC 616.314.17-008.1-084:615.015
Introduction. Weakened, immobile, bedridden patients who occupy a passive position in bed often develop local changes of dystrophic and ulcerative-necrotic changes, decubitus ulcers, which aredetermined by trophycal disturbances of the skin and underlying tissues. Significant risk factors include diabetes mellitus, conditions after cerebrovascular diseases, Parkinson's disease and other neurological pathologies, and exhaustion in patients with insufficient or inadequate care. Modern scientific research is mainly aimed at developing strategies and methods for the treatment of pressure ulcers that have already formed, which is a local purulent-necrotic process. There is no clear consensus on the criteria for readiness of bedsores (which affects the outcome of surgery) for surgical treatment, which ultimately determines the length of the hospital care of palliative patients.
Key words: Purulent-necrotic pathology, pressure ulcers (bedsores, decubitus ulcers), classification criteria, features of prevention, strategies of complex treatment.
The results of research conducted in the last decade testify to the leading role of the vascular endothelium in the regulation of the work of the cardiovascular system, the dynamics of the state of the vascular wall, and the regulation of vascular functions. The intima of vessels provides a dynamic balance between vasodilating and vasoconstrictive factors, regulates the growth and proliferation of subendothelial cells and non-cellular structures, affects vascular permeability [1]. Endothelial cell dysfunction is a characteristic feature of vascular disease and is characterized by a decrease in angiogenic potential and bioavailability of nitric oxide (NO), impaired vasodilation and increased inflammation [2]. The main role in vasodilation belongs to NO [3].
Research in recent years in the field of vascular physiology has shown that the NO molecule, which is synthesized by the vascular endothelium, has a wide range of bioregulatory effects. NO is an unstable short-lived molecule with a half-life of 2-30 seconds, followed by transformation into nitrite and nitrate and excretion in the urine. Both an excess and a deficiency of NO can be significant in the pathogenesis of many diseases, if we take into account its important role in the regulation of the activity of all cells, organs and systems and the vital activity of the organism as a whole in normal and pathological. Despite the enormous physiological importance of NO, the concentration dependence of its activity, basal concentrations, and how its levels fluctuate during certain pathological conditions [4], such as obesity and hypertension - the main components of metabolic syndrome remain unknown [5].
It is believed that vascular endothelium dysfunction plays a leading role in the formation and progression of hypertension. If in adults the issue of the regulatory influence of NO in hypertension is sufficiently studied, in pediatrics it remains open.