The synthesis, anticancer and antimicrobial properties of novel N-aryl-2-(5-aryltetrazol-2-yl)acetamides were discussed. Novel N-aryl-2H-tetrazoles were synthesized and modified in order to obtain the compounds with a satisfactory pharmacological profile. The structures of target substances were confirmed by using 1 H spectroscopy, mass spectrometry and elemental analysis. Anticancer activity screening was carried out within the framework of Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA).
The compounds with significant levels of anticancer activities have been found that can be used for further optimization. The antimicrobial activity of the synthesized substances was evaluated by the value of the MIC and minimum fungicidal and bactericidal concentration. The findings exhibited that the compounds possessed moderate antimicrobial potential

By the reaction of (4-furan-2-yl-thiazol-2-yl)- 3a and (4-thiophen-2-yl-thiazol-2-yl)- 3b acetonitriles with furfural 4 and 5-arylfurfyrals 5a-g 3-furan-2-yl-2-(4-furan/thiophen-2-ylthiazol-2-yl)acrylonitrile derivatives 6a-i were obtained. Anticancer activity screening was carried out within the framework of Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was found out that (2E)-3-(2-furyl)-2-[4-(2-furyl)-1,3-thiazol-2-yl]acrylonitrile (6a) and 2-(4-thiophen-2-yl-thiazol-2-yl)-acrylonitriles 6h,i possessed low activity and 2-(4-furan-2-yl-thiazol-2-yl)acrylonitrile derivatives 6b-g showed moderate action. Compounds 6b-g were sensitive to cell lines of MDA-MB-468 and T-47D Breast Cancer. In this case cytotoxic effect was observed with a range of GP = -38.24 –1.28%.

A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.

Із часу здобуття Україною незалежності, у нашій державі не приділяли належної уваги медичній реабілітації. Ця галузь медицини, спрямована на відновлення або поліпшення функціональних здібностей людей, які перенесли фізичні або психологічні травми, була досить обмежена і не мала системного підходу через різні обставини, зокрема через брак розуміння її важливості як складової здоров’я нації. Однак повномасштабна війна значно прискорила процес формування національної системи реабілітації. 

Since its independence, rehabilitation in Ukraine has been constrained and lacked a systematic approach due to various factors, including insufficient recognition of its significance. Nevertheless, the full-scale war greatly hastened the development of a national rehabilitation system. The increasing demand for medical care for numerous victims of the Russo-Ukrainian war has accelerated the development of infrastructure for physical and psychological support, prioritizing medical rehabilitation in the healthcare system.

Future doctors are expected to possess a high level of professional skills, as reflected by their acquisition of proficient communication competence. The purpose of the article is to determine the role of digital technologies in the formation of communicative competence of prospective doctors. The objective was attained through the use of observation, analysis and weight coefficient, efficiency coefficient, Spearman's correlation coefficient. It was established that the development of communicative competence skills primarily allows to ensure the relevant orientation to the communication conditions (1.6) as well as informativity (1.53). To cultivate the communication proficiencies of prospective medical professionals, the authors developed corresponding approaches that included the use of digital technologies. The study of theoretical material involved the use of the SlideDog application; conducting practical classes via Medvoice Platform. The formation of professional competence involved the role-playing of relevant situations, based on the materials of the Pediatric Dentistry Academy, CARE-NExT-PG. After determining the level of students’ communication skills development in Group 1 (40.2) and Group 2 (40.1), it was established that they attained a high level. The development of communication skills contributed to the formation of students’ communication and social skills, as well as skills of abstract thinking and statistical information processing. The practical significance of the study lies in the elaboration of effective approaches to the development of prospective doctors’ communication skills drawing on the use of digital technologies. Research perspectives may be linked to the comparison of the level of communicative competence among medical students across various academic levels.

 Keywords: communicative and competency skills, digital applications, professional terminology, role- playing the professional situation, transfer of content.