A bisphenol-formaldehyde resin was synthesized using the polycondensation method of bisphenol A with formaldehyde. Road bitumen has been modified with this resin. The possibility of its use as a road petroleum bitumen modifier has been established for different contents of the synthesized resin. It has been established that the introduction of synthesized bisphenol-formaldehyde resin into the composition of bitumen significantly increases its heat resistance. The synthesized resin and modified bitumens were characterized using IR spectroscopy. The change in the composition and properties of the bitumen modified with bisphenol-formaldehyde resin has been described. 

Rhodanines are recognized as privileged heterocycles in medicinal chemistry. The main achievements include the development of drug-like molecules with numerous biological activities as well as approved drugs. The Furan nucleus is considered one of the promising heterocyclic cores in medicinal chemistry that showed numerous ranges of activity. The combination of several heterocycles in a one molecule commonly provides much more interest in the enhanced activity profile of its analogs than their parent separate constituents. Such conjugates are promising objects for modern medicinal chemistry. In this review paper recent advances in the synthesis and biological activities rhodanine-furan conjugates which its application in the different field of drug discovery.

Aim. Study of the synthesis, analysis of ADME - Tox parameters and anti-cancer activity of a series of N-(5-R-benzylthiazole-2-yl)-2-morpholin-4-yl-2-thioxoacetamides.
Methods. Organic synthesis, 1H NMR spectroscopy, analytical method, in silico ADME-Tox analysis and in vitro cytotoxicity assay.
Results. The series of new N-(5-R-benzylthiazole-2-yl)-2-morpholin-4-yl-2-thioxoacetamides was synthesized according to a convenient synthetic method. Their structures were confirmed by 1H NMR spectroscopy and microanalyses. Using the internet resources of SwissADME and pkCSM-pharmacokinetics, the ADME - Tox profiles of the synthesized compounds were calculated. It was determined that the substances were within the optimal limits of  bioavailability. All compounds meet the criteria of drug similarity according to the rules of Lipinski, Weber, Egan and Mugge. It is also determined that low toxicity is predicted for these substances. The synthesized compounds were tested in vitro for their antitumor activity according to the Developmental Therapeutic Program of the National Cancer Institute (NCI) (www.dtp.nci.nih.gov) against 60 cancer lines in the concentration of 10 μM. Human tumor
cell lines from nine different cancer types were used: leukemia, melanoma, lung, colon, CNS, ovarian, kidney, prostate an d breast cancer. Screening results showed that, in most cases, these compounds are of low activity. An exception is the renal cancer line UO-31, which was moderately sensitive to all synthesized compounds.
Conclusions. A series of 2-aminothiazole hybrids containing morpholine moiety was synthesized and studied in silico ADME-Tox profiles. The ADME-Tox profiles indicated good oral bioavailability and low toxicity. Synthesized compounds were tested in vitro for their anti-cancer activity. They showed moderate antiproliferative activity.

New 4-aryl-3-(morpholin-4-yl)-2-arylimino-2,3-dihydrothiazole derivatives 1.1-1.16 were obtained using the Hantzsch reaction by condensation of N-(morpholin-4-yl)-N'-arylthioureas with the corresponding α bromoacetophenones in alcohols. Synthesized hydrobromides 1.1-1.8 were formed as crystalline precipitates during the boiling of the reaction mixture. Bases 1.9-1.16 were obtained by neutralizing the corresponding hydrobromides with NH4OH solution. It has been proposed a possible mechanism of the reaction that is based on the study of the structure of the synthesized compounds. The structures of the synthesized compounds were confirmed by 1H NMR spectroscopy with its special techniques (NOESY and ROESY experiments). It has been shown the formation of the isomer 4-(4'-chlorophenyl)-3-(morpholin-4-yl)-2-(4'-chlorophenylamino)-2.3-dihydrothiazole on the basis of compound 1.14. Pharmacological screening of synthesized derivatives of 4-aryl-2-arylimino-2,3-dihydrothiazole compounds revealed the analgesic effect in the model of visceral pain caused by the introduction of acetic acid to white mice. The anti-inflammatory effect of the synthesized compounds was evaluated in vivo by reducing limb edema in rats with carrageenan-induced inflammation. Thus, the synthesized compounds have analgesic and anti-inflammatory activity.

In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.