Taking into account actuality of psoriasis morbidity problem, specialists point out differentiated individual approach to diagnostic and therapeutic stages as a key aspect in the management of patients. Investigation of main points of etiopathogenesis and elaboration of target influence on its key aspects will enable to achieve a set goal. Both rapid epidermal proliferation and dermal inflammatory infiltration are accompanied by numerous formations of new blood vessels, which start during the early changes of psoriasis and vanish after skin lesion clearance. These observations highlighted that angiogenesis is the chief distinguishing feature during the pathogenesis of psoriasis. Among non-specific stimulants of angiogenesis, matrix metalloproteinase (MMP) should be singled out, which is a group of matrix-destructing enzymes, the source of which are fibroblasts, macrophages, neutrophils and other cells that play an important role in tissue remodelling, including neoangiogenesis processes.